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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Guided Posters

Calcium and Bone 1

ea0063gp15 | Calcium and Bone 1 | ECE2019

Recombinant human parathyroid hormone 1–84 for the treatment of adults with chronic hypoparathyroidism: Six-year safety and efficacy results of the RACE study

Bilezikian John P , Bone Henry , Clarke Bart L , Denham Douglas , Germak John , Lee Hak-Myung , Levine Michael A , Mannstadt Michael , Peacock Munro , Rothman Jeffrey G , Sherry Nicole , Shoback Dolores M , Vokes Tamara J , Warren Mark L , Watts Nelson B

Background: RACE is an open-label study that assessed the long-term safety and efficacy of recombinant human parathyroid hormone 1–84 (rhPTH[1–84]) for the treatment of hypoparathyroidism in adults ( identifier NCT01297309). Here, we present 6-year safety and efficacy data.Methods: Patients initially received 25 or 50 μg of rhPTH(1–84) subcutaneously, once daily, with stepwise dose adjustments of 25 μg (up or do...

ea0063gp16 | Calcium and Bone 1 | ECE2019

The effect of parathyroidectomy on glucose homeostasis and incretin hormone release in patients with primary hyperparathyroidism: a pilot study

Antonopoulou Vasiliki , Grammatiki Maria , Koufakis Theocharis , Karras Spyridon , Yavropoulou Maria , Katsiki Niki , Gerou Spyridon , Gavana Elpida , Skoura Lemonia , Zebekakis Pantelis , Papavramidis Theodosios , Kotsa Kalliopi

Background: Primary hyperparathyroidism (PHPT) has been linked to glucose homeostasis disorders, leading to insulin resistance and type 2 diabetes mellitus. Previous small studies evaluating the effect of parathyroidectomy (PTX) on various parameters of glucose metabolism have produced conflicting results. The impact of PTX on incretin hormone levels has not been studied yet. The aim of this pilot study was to investigate the effect of PTX on markers of glucose metabolism and ...

ea0063gp17 | Calcium and Bone 1 | ECE2019

Utility of a second technecium99mMIBI-SPECT imaging before re-operating in patients with persistent sporadic primary hyperparathyroidism: results of a retrospective multicentric study

Frey Samuel , Couette Clement , Tresallet Christophe , Hamy Antoine , Caillard Cecile , Blanchard Claire , Lhermite Emilie , Menegaux Fabrice , Drui Delphine , Ansquer Catherine , Mirallie Eric

Introduction: Persistent primary hyperparathyroidism (pHPT) occurs in 2.5 to 15% of cases after parathyroidectomy. Pre-operative localization studies (usually 99mTc-MIBI and cervical ultrasonography (US)) allow focused surgical approach (unilateral neck exploration or minimally invasive parathyroidectomy). Few studies have evaluated the best pre-reoperative approaches in case of persistent sporadic pHPT. The aim of our study is to evaluate the value of a second pre-...

ea0063gp18 | Calcium and Bone 1 | ECE2019

Calcium to Phosphorus (Ca/P) ratio as an accurate index for the diagnosis of primary hyperparathyroidism (PHPT) and hypoparathyroidism (HypoPT)

Vincentis Sara De , Repaci Andrea , Altieri Paola , Kara Elda , Vescini Fabio , Amadori Pierluigi , Balestrieri Antonio , Rochira Vincenzo , Madeo Bruno

Background: The diagnosis of PHPT and chronic HypoPT is still challenging, mainly due to the wide spectrum of clinical and biochemical presentation and the lack of validated diagnostic index in literature. The serum Ca/P ratio has been proposed as an accurate tool to diagnose PHPT in a small sample of patients, while no data is available about its possible application for HypoPT.Aim: To validate the serum Ca/P ratio as a diagnostic index for PHPT and to ...

ea0063gp19 | Calcium and Bone 1 | ECE2019

18F-Fluorocholine PET/CT in patients with primary Hyperparathyroidism and negative or inconclusive 99mTc-MIBI parathyroid scan: clinico-pathological correlations

Minambres Inka , Farran Judit Amigo , Lopez Diego Alfonso , Estorch Montserrat , Perez Jose Ignacio , Moral Antonio , Clos Montserrat , Ballester Eulalia , Chico Ana

Introduction: The gold standard for evaluating Occult Parathyroid Adenomas (OPa) in patients with biochemical pattern of primary hyperparathyroidism (PHPT) is the 99mTc-MIBI parathyroid scan. 18F-Fluorocholine (18F-FCH) PET/CT has been proposed as a potential technique for detection and localization of OPa when 99mTc-MIBI scan is negative or inconclusive.Aims: To evaluate sensitivity and positive predictive value of 18F-Fluorocholine PET/CT in patients w...

ea0063gp20 | Calcium and Bone 1 | ECE2019

Clinical, biochemical and radiological profile of normocalcaemic hyperparathyroidism: a multicentric cross-sectional evaluation

Naciu Anda Mihaela , Tabacco Gaia , Falcone Stefania , Santonati Assunta , Maggi Daria , D'Onofrio Luca , Briganti Silvia Irina , Castellitto Domenico , Casini Alessandro , Pedone Claudio , Fabbri Andrea , Napoli Nicola , Pozzilli Paolo , Manfrini Silvia , Cesareo Roberto , Palermo Andrea

Background: The normocalcaemic hyperparathyroidism (NHPT) has been defined as a condition with persistently normal total and ionized calcium levels in the presence of high levels of PTH. The clinical aspects of NHPT have been evaluated in different cohorts but the interpretation of these findings is confounded by differing methods used to rule out secondary hyperparathyroidism and by the small number of NHPT subjects enrolled. Up to now, there is no information available that ...

ea0063gp21 | Calcium and Bone 1 | ECE2019

The long-term outcomes of chronic post-surgical hypoparathyroidism

Mokrysheva Natalia , Eremkina Anna , Kovaleva Elena

Hypoparathyroidism (HP) is a rare disease characterized by an absence or inappropriately low concentrations of circulating parathyroid hormone, leading to hypocalcaemia, hypophosphatemia and elevated urinary calcium excretion.Aim: To determine complications in chronic post-surgical HP patients.Material and methods: We have analyzed the data from 76 patients (71 women and 5 men; median age 51.8 years (range 18–77)) with chronic...

ea0063gp22 | Calcium and Bone 1 | ECE2019

OFELIA – Prevalence of osteoporosis in fragility fracture patients

Tei Randi , Plana-Ripoll Oleguer , Brink Ole , Langdahl Bente

Worldwide, a care gap has been recognized between presenting with a fragility fracture and prevention of the next fracture. Fracture Liaison Service is the most cost-effective method to close this gap, but its implementation is sparse in many countries. To assess the need for a subsequent fracture prevention program in Denmark, we conducted a cross-sectional study – named OFELIA - aiming to estimate the prevalence of osteoporosis in a Danish cohort of fragility fracture p...

ea0063gp23 | Calcium and Bone 1 | ECE2019

Study of hsa-miR-30e miRNA as a biomarker in identifying multiple gland disease in sporadic primary hyperparathyroidism: Is it time for individualized molecular-based surgery?

Mizamtsidi Maria , Nastos Konstantinos , Palazzo Fausto , Constantinides Vasilis , Dina Roberto , Farenden Megan , Vassiliou Ioannis , Gazouli Maria

Introduction: Sporadic primary hyperparathyroidism (sporadic PHPT) is a common endocrine disorder, usually caused by a single parathyroid adenoma. However, up to 15% of patients present with multiple gland disease (MGD), which cannot be always diagnosed preoperatively, raising serious management problems. No predictive genetic screening tests are currently available to distinguishing adenomas from MGD in sporadic PHPT. MiRNAs are widely established as genetic molecules that ha...

ea0063gp24 | Calcium and Bone 1 | ECE2019

The impact of impaired calcium-phosphorus metabolism on the renin-angiotensin-aldosterone system in patients with primary hyperparathyroidism

Mokrysheva Natalia , Dobreva Ekaterina , Bibik Ekaterina , Eremkina Anna

Objective: Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity including hypertension with a prevalence ranging from 40 to 65%. The renin-angiotensin-aldosterone system (RAAS) is a key system in the regulation of sodium/potassium balance, volume homeostasis as well as blood pressure. There is increasing evidence of interactions between calcium and calcium-regulatory hormones with the RAAS. The aim of this study was to investigate the associ...

ea0063gp25 | Calcium and Bone 1 | ECE2019

Impact of chronic hypoparathyroidism on health-related quality of life, symptoms, employment, and relationships: findings from a 13-country patient survey

Bollerslev Jens , Bent-Ennakhil Nawal , Chen Kristina , Clarke Bart L , Dahl-Hansen Helen , Germak John , Gibson Katie , Glenister Elizabeth , Judge Davneet , Marelli Claudio , Siggelkow Heide

Significant knowledge gaps exist regarding the humanistic effects of hypoparathyroidism, a rare, debilitating disorder. We report results from a global survey to characterise the burden of hypoparathyroidism from the patient perspective. An anonymous survey was conducted in patients with uncontrolled chronic hypoparathyroidism (as determined by patients’ report of persistent symptoms and/or poorly controlled calcium levels as told by their physician) despite receiving con...