Endocrine Abstracts

Bone is not only a skeletal scaffold but also an endocrine organ. Its formation and remodeling initiate from the recruitment and subsequent differentiation of mesenchymal stem cells (MSCs), in which the signals are known to be dominated by SMAD2/3 signaling driven by TGF-βs and SMAD1/5/8 signaling driven by BMPs, respectively. Of interest, distinct from the above concepts, we found that TGF-β1 induces not only SMAD2/3 phosphorylation but also SMAD1/...

Background: Canonical Wnt-signalling is important for bone by regulating osteoblastogenesis and osteoblast function. Bone metabolism is also partly determined by sex steroid exposure and sex differences in serum sclerostin levels have been reported. However, it is unclear whether serum sclerostin and other circulating Wnt-signalling components are sex steroid dependent within healthy men.Objective: To determine whether serum sclerostin, osteoprotegerin (...

Introduction: Several risk factors are involved in post-liver transplantation osteoporosis. Immunosuppressive agents, glucocorticoids, decreased renal function associated with secondary hyperparathyroidism and immobilization are the main determinants of fragility fractures in this population. Denosumab is highly effective in increasing bone mineral density (BMD) and preventing fragility fractures. However, the efficacy of denosumab in liver transplantation osteoporosis has nev...

Background: Long standing growth hormone (GH) excess causes the skeletal clinical signs of acromegaly with typical changes in bone geometry including increased cortical bone thickness (CBT). However, a high prevalence and incidence of vertebral fractures has been reported. The aim of this study was to assess the course of cortical bone dimensions in the hip by comparing patients with acromegaly and clinically non-functioning pituitary adenomas (NFPA) at baseline and one year a...

The aim of the study was to evaluate the degree of muscle dysfunction and relationship of trunk muscle strength and body composition in patients with osteoporotic vertebral fractures (VFs). Methods. Study comprised 90 men and woman 40-80 years old with primary osteoporosis. Study group (n=60) included patients with at least 1 VF (confirmed by X-rays), control group (n=30) consisted of osteoporotic patients of the same age, BMI and BMD without any fracture. Trunk muscl...

According to numerous studies, type 2 diabetes mellitus (T2DM) is associated with an increased risk of low traumatic non-vertebral fracture. There are a limited number of studies which evaluate lateral vertebral X-Rays in order to diagnose vertebral fractures in patients with T2DM. The goal of our study was to investigate the difference in vertebral fracture rate registered on lateral X-Ray between subjects with T2DM and a control group being under observation in the same outp...

Background and aims: Diabetic osteopathy in patients with type 1 diabetes (T1DM) is obvious. However, approaches to its diagnosis are still ambiguous. Thus, the aim was to study the features of serum osteo-specific parameters and dual energy X–ray absorptiometry (DXA) data in T1DM patients.Materials and methods: 157 patients with T1DM (105 women, 52 males) (mean age: 32.5 (25.5–41.6) yrs, duration of DM: 13 (7–20) yrs, age of manifestation...

Introduction: Central obesity and the consequent metabolic syndrome have global devastating effect on the health system due to their strong association with type 2 diabetes mellitus and cardiovascular disorder. There are contradictory results about the influence of insulin resistance and visceral adipose tissue on bone phenotype. The study was designed to evaluate the association between bone quality and bone mineral density (BMD) with bone marrow adipose tissue (MAT) as well ...

Aim: Fibroblast growth factor-23 (FGF-23) has been proposed as a predictor of bone abnormalities in chronic kidney disease patients (CKD), with recent data showing that it may also predict bone mass in the general population. We aimed at investigating the relationship between FGF-23 and bone mass parameters in apparently healthy individuals, according to sex, menopausal and nutritional status.Materials and methods: Bone mass (bone mineral density-BMD, bo...

Introduction: Craniopharyngioma (CP) is a benign tumor of the sellar/hypothalamic region. It is associated with excess mortality, obesity and endocrinopathies. These endocrinopathies may influence bone health, and increase the risk of fractures.Methods: In this retrospective study, Dutch/Swedish patients with CP were included if data was available on final height (at age >18 years) or DXA-scan results. Information from the first and last DXA-scans we...

Purpose: Osteopathy/osteoporosis in Gaucher disease type 1 (GD1) shows variable responses to enzyme replacement therapy (ERT); the pathogenesis is incompletely understood. We aimed to investigate the effect of several gene variants on bone mineral density (BMD) and serum markers of bone metabolism in GD1.Patients/methods: 50 adult Caucasian patients with GD1/117 controls were genotyped for gene variants in the osteoprotegerin (TNFRSF11B; OPG), estrogen r...