Endocrine Abstracts

Background: Glucose variability (GV) is common among hospitalized patients but the prognostic implications among patients hospitalized to surgical wards are unknown.Objective: Investigate the association between GV, length of stay (LOS) and mortality.Methods: Historical prospectively collected data of patients ≥18 years, hospitalized to general surgery wards between January 2011–December 2017. GV was assessed by coeffici...

Introduction: A growing body of evidence is supporting a beneficial impact of breastfeeding on maternal metabolism and overall cardiovascular risk. The aim of this study was to evaluate the association between prolactin levels and metabolic parameters as well as indices of subclinical atherosclerosis, in a sample of premenopausal women with normal levels of prolactin.Patients and Methods: This cross-sectional study included a total of 64 non-lactating pr...

Background and aims: Diabetic retinopathy (DR) is an important chronic complication of diabetes mellitus (DM), and is the leading cause of new cases of blindness in adults. Although several single nucleotide polymorphisms (SNPs) have been associated with DR, more information is needed to unravel the genetics of this complex disease. MicroRNAs (miRNAs) are a class of small noncoding RNAs that regulate expression of at least 60% of all protein-coding genes. A number of miRNAs ha...

Hypothesis: High doses of vitamin D (VitD) improves dermal microcirculation (MC) in diabetic patients with type 2 diabetes mellitus (T2DM) and diabetic neuropathy (DN).Purpose: To study the effect of different VD doses on skin MC values in T2DM patients and DN.Materials and methods: Sixty-two non-smoking T2DM patients with DN were randomized into two groups: Group 1 received 5000 IU (G1) and Group 2 received 40000 IU (G2) of cholec...

Objectives: This study was undertaken to ascertain the prevalence of hearing loss (HL) in patients with Type 2 Diabetes (T2DM) and to understand its relationship with diabetic neuropathy.Materials and Methods: Patients between the ages of 30 to 60 years (both ages inclusive) with T2DM were recruited and divided in two groups. Group 1 with moderate to severe distal sensory-motor neuropathy (Michigan Diabetic Neuropathy Score >12) or Group 2 were those...

Aim: Loss of protective sensation (LOPS) commonly precede Diabetic foot ulcer (DFU) which is one of the most fearsome/serious diabetic complications and the leading cause of foot amputation in T2D patients. However, the prevalence of this high risk state is unknown.Methods: To estimate the presence of LOPS among hospitalized diabetes patients in internal wards, vibration perception and 10-g monofilament tests were done. Patients with foot ulcer or status...

Introduction: Recently, vitamin D3 (cholecalciferol) deficiency has been considered as one of the factors for the development of type 2 diabetes mellitus (T2D) and metabolic syndrome (MS), which contributes to increased insulin resistance (IR) and reduced insulin secretion. The most pronounced vitamin D deficiency is observed in persons suffering from morbid obesity. The aim of this study was to assess IR, b-cell functional activity and metabolic profile parameters according t...

Aims: Diabetes is an important health condition in the aging population. The risk of depression is increased in older adults and should therefore be screened and managed. Especially, it is important to early detect and improvement of depression in older adults with diabetes because it is associated with glucose control and development of diabetic complication. We evaluated the prevalence of depression in diabetic older adults and identified associated independent risk factors ...

It is known that presence of certain genetic polymorphism plays important role in development of chronic complications in patients with type 2 diabetes (T2D).Aim: To analyze distribution of VEGF G/C polymorphisms and PAI-1 4G/5G polymorphisms in patients with T2D and IHD.Materials and methods: The following groups of studies were formed: 1 – 24 almost healthy people; 2 – 28 patients with prediabetes; 3 – 37 patients ...

Introduction: The purpose of this study was to describe the clinical and metabolic characteristics of a population of diabetic patients previously educated and having fasted all month of Ramadan.Methods: This is a prospective study that involved 140 patients who wish to fast the month of Ramadan (2016).They presented themselves at consultations dedicated to preparing diabetic patients wishing to fast, organized at the National Institute of Nutrition of T...

Aim: To investigate the clinical efficacy of the treatment of patients with neuro-ishemic diabetic foot ulcers (DF) by using sorption-antimicrobial nanocomposition based on silica sorbents.Methods: Hydrophobic-hydrophilic sorption-antibacterial nanocomposition, offered for the treatment of ulcers and wounds, contains sorbents (nano-disperse silicon dioxide, polymethylsiloxane) and antibacterial components (decamethoxin, metronidazole). In this study 78 p...