Searchable abstracts of presentations at key conferences in endocrinology
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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Guided Posters


ea0063gp130 | Obesity | ECE2019

Glucagon activity in human adipose precursors

Trabucco Martina , Cantini Giulia , Mannucci Edoardo , Luconi Michaela

Obesity is associated with increased and dysfunctional white adipose mass. In the past, pharmacological approaches have not yielded significant results in terms of stable weight loss. Glucagon-like peptide 1 receptor (GLP-1R) agonists (GLP-1RA) used for the treatment of type 2 diabetes have more recently been proposed as anti-obesity drugs due to their relevant effects on weight loss. Furthermore, dual agonists engaging both GLP-1R and glucagon receptor (GCGR) are under invest...

ea0063gp131 | Obesity | ECE2019

A Study of the Effect of Laparoscopic Mini Gastric Bypass Versus Sleeve Gastrectomy On Obese Type 2 Diabetic Patients

Aboromia Maram M , Farahat Mahmoud , Mortada Ahmed , Elmaleh Haitham , Elsherbiny Alyaa , Eldin Ahmed Bahaa

Recent guidelines on diabetes treatment provide that bariatric surgery should be the most logical & cost-effective means of controlling Type 2 diabetes.Objectives: To compare laparoscopic mini-gastric bypass vs laparoscopic sleeve gastrectomy regarding the efficacy of control of D.M in obese patients.Summary: A randomized controlled study conducted on 60 obese patients with type 2 D.M divided into, group (1): 30 patients treate...

ea0063gp132 | Obesity | ECE2019

Variants in genes of the leptin / melanocortin pathway are involved in 3% of cases of early-onset severe obesity

Bihan Johanne Le Beyec-Le , Poitou-Bernert Christine , Karsenty Alexandra , Pelloux Veronique , Lacorte Jean Marc , Tounian Patrick , Oppert Jean Michel , Clement Karine , Dubern Beatrice

The leptin/melanocortin pathway plays a critical role in hypothalamic control of food intake. Variants in the genes involved in this pathway, such as leptin (LEP), its receptor (LEPR), proopiomelanocortin (POMC) or proconvertase 1 (PCSK1) are associated with early-onset severe obesity and endocrine abnormalities especially in case of homozygosity. Heterozygous variants in the melanocortin-4 receptor (MC4R) gene are associated with an increased risk of severe obesity. The aim i...

ea0063gp133 | Obesity | ECE2019

Effect of IL1-receptor antagonist on renin-angiotensin-aldosterone system and hemodynamics in obese individuals

Urwyler Sandrine , Ebrahimi Fahim , Burkard Thilo , Schuetz Philipp , Poglitsch Marko , Beat Mueller , Donath Marc Y , Christ-Crain Mirjam

Background: Interleukin (IL)-1 antagonism decreases systolic blood pressure in obese individuals. However, the underlying mechanism is unknown. Based on experimental data in animals we hypothesised a blood-pressure lowering effect of IL-1-antagonism via modulation of the renin-angiotensin-aldosterone system (RAAS).Methods: In this post-hoc explorative study, we examined short- (2 days) and long-term effects (4 weeks) of IL-1 antagonism (anakinra/Kineret<...

ea0063gp134 | Obesity | ECE2019

Higher habitual intakes of dietary carbohydrates are associated with leptin gene expression in visceral and subcutaneous adipose tissues among non-diabetic people

Yuzbashian Emad , Zarkesh Maryam , Asghari Golaleh , Hedayati Mehdi , Mirmiran Parvin , Khalaj Alireza

Introduction: Leptin is a well-known adipokine which has a critical role in the regulation of body weight, body fat mass, appetite, and food intakes. Energy-supplying nutrients such as carbohydrates is a dietary-related factor which has potential effects on plasma leptin levels. The effect of habitual carbohydrates intake on leptin gene expression was limited only in animal studies. The current study aimed to investigate the association of habitual carbohydrate intake with lep...

ea0063gp135 | Obesity | ECE2019

Obesity is associated with a downregulation of UCP2 and miR-133a-3p but not NLRP3 in subcutaneous adipose tissue

Souza Bianca de , Oliveira Mayara de , Rheinheimer Jakeline , Moehlecke Milene , Rodrigues Michelle , Leitao Cristiane , Crispim Daisy

Background and aims: Obesity is a chronic multifactorial disease characterized by an excessive accumulation of body fat resulting from an imbalance between energy intake and caloric expenditure. Uncoupling protein 2 (UCP2) is located in the inner mitochondrial membrane and plays an important role in the regulation of energy expenditure. NLR family, pyrin domain-containing 3 (NLRP3) inflammasome seems to have a key role in obesity-induced inflammation through production of the ...

ea0063gp136 | Obesity | ECE2019

Administration of a growth hormone bolus down-regulates gene-expression of the g0/g1 switch gene 2 (g0s2) in subcutaneous adipose tissue in healthy, obese men: a randomized, placebo-controlled, cross-over study

Hjelholt Astrid , Jessen Niels , Arlien-Soborg Mai Christiansen , Pedersen Steen Bonlokke , Jorgensen Jenso Otto Lunde

Background: Growth hormone (GH) potently stimulates lipolysis, and after GH exposure, levels of serum free fatty acids (FFAs) increase in a distinct temporal pattern characterized by a 1-hour lag phase and a peak after 3 hours followed by a gradual return to baseline. This effect predominantly operates during fasting and promotes utilization of lipids from adipose tissue (AT) at the expense of glucose and protein. Prolonged fasting also downregulates the expression of the G0/G...

ea0063gp137 | Obesity | ECE2019

Empagliflozin as well as Anakinra reduce symptomatic hypoglycemia in patients after Roux-Y-gastric bypass by lowered insulin secretion

Hepprich Matthias , Wiedemann Sophia , Schelker Benjamin , Starkle Alessandra , Trinh Beckey , Boni-Schnetzler Marianne , Rudofsky Gottfried , Donath Marc

Background: Postprandial hypoglycemia is an increasingly recognized complication after bariatric surgery. Its hallmark is a pronounced glycemic rise after carbohydrate ingestion followed by an exaggerated hyperinsulinemic response. Recent studies have shown that IL-1β contributes to postprandial stimulation of insulin. Furthermore, inhibition of SGLT2 reduces excessive plasma glucose increase. Therefore, we investigated whether inhibition of IL-1β with the IL-1 recep...

ea0063gp138 | Obesity | ECE2019

Androgen metabolism during weight loss in men with obesity

Velde Frederique Van de , Deventer Koen , Gansbeke Wim Van , Eenoo Peter Van , Renterghem Pieter Van , Fiers Tom , Kaufman Jean-Marc , Nieuwenhove Yves Van , Lapauw Bruno

Background: Men with obesity often have low total and, with increasing adiposity, also free testosterone (T) levels, which can partially restore when they lose weight. Although this is in part explained by lower sex-hormone binding globulin (SHBG) production and hypothalamic-pituitary downregulation, it is still not fully unraveled whether changes in androgen metabolization contribute to this phenomenon.Aim: Investigating metabolisation of sex steroids d...

ea0063gp139 | Obesity | ECE2019

Prediction of clinically significant weight loss with Gelesis100 in the GLOW study as early as 8 weeks post-treatment

Luzi Livio , Raben Anne , Astrup Arne , Matejkova Erika , Svacina Stepan , Gnessi Lucio , Navas-Carretero Santiago , Martinez J Alfredo , Greenway Frank , Aronne Louis , Apovian Caroline , Kaplan Lee , Hill James , Fujioka Ken , Still Christopher , Sannino Alessandro , Saponaro Cosimo , Calderon Henry , Urban Lorien , Chiquette Elaine , Leider Harry , Ron Eyal , Zohar Yishai , Heshmati Hassan

Introduction: Identification of early responders is widely used in pharmacotherapy for weight loss to minimize unnecessary exposure to risks and unnecessary expenses. Gelesis Loss Of Weight (GLOW; NCT02307279), a multicenter, double-blind, placebo-controlled pivotal study, demonstrated that Gelesis100 offers a compelling new potential approach in the management of overweight and obesity.Objective: A post-hoc area under the curve (AUC) for the receiver op...

ea0063gp140 | Obesity | ECE2019

The efficacy of complex kinesiotherapy in weight loss and muscle function improving in obesity patients

Vasileva Valeriia , Marchenkova Larisa , Eryomushkin Mikchail , Razvalyaeva Daria

Aim of the study was to estimate the effect of complex 3-week treatment with 4 kinesiotherapy methods on body weight loss and muscle function in patients with obesity.Material and methods: 80 men and women aged 21-69 years old with alimentary obesity were enrolled in the study (mean age 52.4±11 years, weight 111.3±24.5 kg, BMI 40.3±8.1 kg/m2, waist circumstance WC 113.4±16 cm, hip circumstance HC 124.2±16 cm). The comp...

ea0063gp141 | Obesity | ECE2019

Dietary inflammatory index is differently associated with ectopic fat depots in overweight and obese adults

Poggiogalle Eleonora , Lubrano Carla , Luisi Federica , Hebert James R , Shivappa Nitin , Di Martino Michele , Gnessi Lucio , Mariani Stefania , Lenzi Andrea , Donini Lorenzo M.

Introduction: In overweight and obesity energy unbalance is responsible for the accumulation of ectopic fat. Excess energy and metabolic alterations, namely insulin resistance, may favor ectopic fat depositions. However, the role played by dietary factors, especially the pro-inflammatory properties of dietary patterns, in ectopic fat storage is not thoroughly understood. The aim of our study was to investigate the association between the Dietary Inflammatory Index (DII) and di...