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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Guided Posters

Disturbances of Reproduction

ea0063gp245 | Disturbances of Reproduction | ECE2019

MRI detection of aortic anomalies in 204 adult patients with Turner syndrome: a longitudinal study

Donadille Bruno , Tuffet Sophie , Bourcigaux Nathalie , Nedelcu Mariana , Monnier-Cholley Laurence , Rousseau Alexandra , Christin-Maitre Sophie , And Heart Study Group Turner

Mortality is 3 fold higher in patients with Turner syndrome (TS) than in the general population, primarily due to cardiovascular complications. Recent clinical guidelines (Gravholt et al. EJE 2017) underlined the need of a lifelong cardiovascular follow-up. However, prospective studies evaluating the aortic natural history in clinical practice are scarce. We performed a monocentric longitudinal study including 204 adult TS patients, between 2005 and 2018. Inclusion criteria we...

ea0063gp246 | Disturbances of Reproduction | ECE2019

Is monosomia related to poorer cardiometabolic state in Turner syndrome?

Kriksciuniene Ruta , Zilaitiene Birute , Lukosevicius Saulius , Verkauskiene Rasa

Introduction: 45,X karyotype is known to be related to more severe phenotype disorders, still comparative analysis of the karyotypes and phenotypes in Turner syndrome (TS) is difficult, even in the largest studies, mainly due to differences in patient‘s age and variability in the definition of clinical features (1). We aimed: to assess if monosomia in Turner syndrome patients is related to their cardiometabolic features.Methods: 75 females with conf...

ea0063gp247 | Disturbances of Reproduction | ECE2019

The efficacy of long-term metformin treatment in overweight and obese women with PCOS: A 10-year database study

Jensterle Mojca , Aleksandra Kravos Nika , Goricar Katja , Janez Andrej

Context: Metformin is an established therapy for women with PCOS and pre-diabetes or diabetes when lifestyle modification is insufficient. Metformin should also be considered in women with PCOS with BMI≥25 kg/m2 independently of the presence of metabolic disturbances. However, its long-term efficacy in this subset of patients is inadequately studied.Aim: We analyzed collection data of 10 years for the efficacy of metformin on body mass (...

ea0063gp248 | Disturbances of Reproduction | ECE2019

Gut microbiota-dependent cardiometabolic risk and oral contraceptive use in polycystic ovary syndrome: A prospective study

Eyupoglu Damla , Caliskan Guzelce Ezgi , Acikgoz Aylin , Uyanik Esra , Bjorndal Bodil , Berge Rolf , Svardal Asbjorn , Okan Yildiz Bulent

Context: Polycystic ovary syndrome (PCOS) is associated with an increased cardiometabolic risk that might not necessarily translate into adverse cardiovascular outcome later in life. Recently, alterations in gut microbial composition have been reported in the syndrome. Microbiota-dependent metabolite trimethylamine N-oxide (TMAO) and its precursors are closely linked with development of atherosclerotic cardiovascular disease, independently of traditional risk factors.<p cl...

ea0063gp249 | Disturbances of Reproduction | ECE2019

Maternal 3rd trimester cortisol status was associated with offspring sex and PCOS status. Odense Child Cohort

Andersen Marianne , Jensen Richard , Schmedes Anne , Brandslund Ivan , Kyhl Henriette , Jensen Tina , Glintborg Dorte

Background: Maternal circulating cortisol and 24-h urinary free cortisol levels are up to three times higher in third trimester pregnant women compared to non-pregnant women. Maternal cortisol status could be associated with offspring sex, maternal PCOS and testosterone levels.Aims: To determine predictors of maternal serum (S) and urinary (U) cortisol and cortisone levels during 3rd trimester and to examine associations between maternal cortisol status,...

ea0063gp250 | Disturbances of Reproduction | ECE2019

Diagnostic potential of a ‘mouse azoospermia’ gene panel in human azoospermia: identification of novel genetic causes of meiotic arrest

Riera-Escamilla Antoni , Enguita-Marruedo Andrea , Moreno-Mendoza Daniel , Chianese Chiara , Ruiz-Castane Eduard , Maggi Mario , Baarends Willy , Krausz Csilla

Purpose: Non-Obstructive Azoospermia (NOA), occurring in approximately 1% of men, has an unknown etiology in the majority of cases. This study aims at evaluating the diagnostic efficiency of a gene panel contemplating all known genes associated with azoospermia in mice.Subjects and methods: Design of a ‘mouse azoospermia’ gene panel through the consultation of MGI; selection of 175 mouse azoospermia genes with human orthologues; selection of 31...

ea0063gp251 | Disturbances of Reproduction | ECE2019

Free Testosterone (FT) is inversely related to frailty in Human Immunodeficiency Virus (HIV)-Infected Men

De Vincentis Sara , Decaroli Maria Chiara , Diazzi Chiara , Morini Fabio , Bertani Davide , Fanelli Flaminia , Mezzullo Marco , Santi Daniele , Tartaro Giulia , Baraldi Enrica , Tagliavini Simonetta , Pagotto Uberto , Guaraldi Giovanni , Rochira Vincenzo

Background: HIV-infection is associated to several age-related comorbidities, such as a premature decline of serum testosterone (T). There is evidence about the relationship between health status, represented by frailty and comorbidities, and serum T levels in general population, while only one previous retrospective study investigated it in HIV-infected men.Aim: To investigate the association between frailty and gonadal status by assessing serum total T...

ea0063gp252 | Disturbances of Reproduction | ECE2019

Prolactin and prostate: an observational case-control study in men with prolactinoma under cabergoline treatment

Garifalos Francesco , De Alcubierre Dario , Verde Nunzia , Menafra Davide , Arnesi Mauro , de Angelis Cristina , Colao Annamaria , Auriemma Renata Simona , Pivonello Rosario

Prolactin (PRL) exerts independent hypertrophic effects on prostate in in vivo and in vitro experimental models, and prostatic PRL receptors are known to activate cell proliferation pathways such as MAPK and STAT. Nevertheless, in men with hyperprolactinemia the risk of prostate cancer has been found reduced suggesting a role of concomitant hypogonadism. Chronic cabergoline treatment generally normalizes PRL treatment and improves gonadal function. The curren...

ea0063gp253 | Disturbances of Reproduction | ECE2019

Genetic architecture of greek patients with isolated GnRH deficiency

Stamou Maria , Varnavas Petros , Plummer Lacey , Koika Vassiliki , Georgopoulos Neoklis

Introduction: Isolated Gonadotropin Releasing Hormone (GnRH) Deficiency (IGD) is a rare disease with a wide spectrum of reproductive and non- reproductive clinical characteristics and is mainly characterized by hypogonadotropic hypogonadism with anosmia (Kallmann Syndrome) or normal olfactory function (Normosmic Idiopathic Hypogonadotropic Hypogonadism- nIHH). Apart from the phenotypic heterogeneity IGD is also highly genetically heterogeneous with >35 genes impli...