Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 63 | ECE2019 | Next issue

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

Card image cap
18-21 May 2019, Lyon, France

Guided Posters

Gestational and Type 1 Diabetes

ea0063gp212 | Gestational and Type 1 Diabetes | ECE2019

Prevalence of gestational diabetes during 14 pregnancies of acromegalic women

Vialon Magaly , Grunenwald Solange , Mouly Celine , Vezzosi Delphine , Bennet Antoine , Caron Philippe

Introduction: Abnormalities of glycoregulation are frequent in acromegaly (15-38%) secondary to insulin resistance related to GH/IGF-1 hyper-secretion. The frequency of gestational diabetes (GD) in women with acromegaly was reported in the French multicenter study (JCEM, 2010, 95, 4680) as increased mainly in the absence of pre-gestational control of GH/IGF-1 hyper-secretion. The aim of this study was to evaluate the frequency of GD in a cohort of acromegalic women, and compar...

ea0063gp213 | Gestational and Type 1 Diabetes | ECE2019

The impact of the intrauterine hyperglycaemia on the expression of genes related to cardio-metabolic diseases in human umbilical vein endothelial cells: results from a randomised, controlled study of different glycaemic targets during gestational diabetes treatment

Popova Polina , Vasileva Liudmila , Tkachuck Alexandra , Puzanov Maxim , Golovkin Alexey , Bolotko Yana , Pustozerov Eugenii , Gerasimov Andrey , Zazerskaya Irina , Dmitrieva Renata , Kostareva Anna , Grineva Elena

Background: Understanding the mechanism whereby the intrauterine hyperglycemia in women with gestational diabetes mellitus (GDM) affects the offspringÂ’ predisposition to metabolic and cardiovascular diseases may help prevent their intergenerational transmission. Our aim was to study the effect of the degree and duration of maternal hyperglycemia on the level of expression of genes associated with cardio-metabolic diseases in human umbilical vein endothelial cells (HUVECs)...

ea0063gp214 | Gestational and Type 1 Diabetes | ECE2019

Association between sleep disturbances and fear of hypoglycemia in adults with type 1 diabetes, data from VARDIA Study

Suteau Valentine , Saulnier Pierre-Jean , Wargny Matthieu , Gand Elise , Chaillous Lucy , Dubois Severine , Allix Ingrid , Bonnet Fabrice , Leguerrier Anne-Marie , Fradet Gerard , Crespin Isabelle Delcourt , Kerlan Veronique , Gouet Didier , Perlemoine Caroline , Ducluzeau Pierre-Henri , Pichelin Matthieu , Gonder-Frederic Linda , Ragot Stephanie , Hadjhadj Samy , Cariou Bertrand , Briet Claire

Aims: To assess the relationship between sleep quality and fear of hypoglycemia, glycemic variability and other diabetes-related outcomes in type 1 diabetes.Methods: Our data were provided by the VARDIA Study, a multicentric observational cross-sectional study conducted between June and December 2015. Sleep characteristics were assessed by Pittsburgh Sleep Quality Index (PQ1I). Fear of hypoglycemia was measured with the Hypoglycemia Fear Survey version I...

ea0063gp215 | Gestational and Type 1 Diabetes | ECE2019

Brain volume and variability of glycemia in patients with type 1 diabetes mellitus

Rotkank Maria , Samoylova Julia , Zhukova Natalia , Matveeva Mariia , Tolmachev Ivan

Actuality: Currently, there is no doubt about the negative effect of diabetes mellitus (DM) on the state of the central nervous system. One of the pathological manifestations are anatomical changes in the brain, which in turn can lead to the development of functional disorders and cognitive decline. Conducting imaging research methods allows us to assess the presence or absence of brain atrophy at an early stage.The aim: To identify the relationship betw...

ea0063gp216 | Gestational and Type 1 Diabetes | ECE2019

Specific pattern of insulin delivery during pregnancy in tightly controlled type 1 diabetic patients treated with insulin pump; unchanged total daily insulin dose per kilogram with consecutive basal/prandial insulin ratio adjustment

Baretić Maja , Lekšić Glorija , Ivanišević Marina

Introduction: Insulin is standard of care for the treatment of type 1 diabetes (T1DM). Constant insulin adjustment is necessary to keep up with the different insulin requirements of pregnancy. Rapid, flexible and precise dosing of basal insulin and advanced options of bolus calculator settings for prandial insulin make insulin pump optimal solution.Aim: The aim of the study was to explore pattern of insulin dynamic in pregnancies of T1DM patients with ti...

ea0063gp217 | Gestational and Type 1 Diabetes | ECE2019

The rs2304256 A allele in the TYK2 gene is associated with protection for type 1 diabetes mellitus in a Brazilian population

Crispim Daisy , Pellenz Felipe Mateus , Duarte Guilherme , Dieter Cristine , Souza Bianca de

Background and Aims: Type 1 diabetes mellitus (T1DM) is caused by an autoimmune destruction of pancreatic beta cells, which renders patients insulin-dependent for life. The disease arises from a complex interaction among several genetic and environmental factors. To date, single nucleotide polymorphisms (SNPs) in >50 genes have been associated with T1DM, with HLA class II SNPs having the greatest impact on disease susceptibility. Other loci have minor effects on T...

ea0063gp218 | Gestational and Type 1 Diabetes | ECE2019

Effect of HbA1c and hyperglycemia on hemostasis in patients with type 1 diabetes

Sarkisova Karina , Jarek-Martynowa Iwona-Renata , Shestakova Marina , Chirkova Lydia , Nikankina Larisa , Shamkhalova Minara

Background and aims: Hyperglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hyperglycemia have not been extensively studied. The aim of this study was to assess the impact of level of fasting plasma glucose, HbA1c on the platelet activity, the physiological anticoagulant activity and fibrinolysis in patients with Diabetes Mellitus type 1 (DM1).Ma...

ea0063gp219 | Gestational and Type 1 Diabetes | ECE2019

Impact of type 1 diabetes mellitus and its complications on markers of nitric oxide metabolism

Sokolovska Jelizaveta , Ošina Kristīne , Baumane Larisa , Pahirko Leonora , Sjakste Nikolajs

Background and aim: The role of derangements of nitric oxide (NO) metabolism in the pathogenesis of complications of type 1 diabetes mellitus (T1D) is not sufficiently clear. There is little data on simultaneous measurements of NO metabolites nitrite and nitrate (NO2/NO3) in urine and serum in T1D. Data about the measurement of NO production by electronparamagnetic spectroscopy (EPR) in whole blood in T1D were never published. To fill this gap we have cha...

ea0063gp220 | Gestational and Type 1 Diabetes | ECE2019

Definition of a third-trimester HbA1c cut-off point for an increased risk of Large-for-Gestational-Age in mothers with Gestational Diabetes

Fonseca Liliana , Duarte Diana Borges , Amado Ana , Lau Eva , Pichel Fernado , Goncalves Joaquim , Pinto Clara , Vilaverde Joana , Dores Jorge , Cardoso Helena

Introduction: Gestational diabetes mellitus (GDM) is associated with important neonatal risks and a higher incidence of large-for-gestational-age (LGA) newborns and fetal macrosomia. The aim of our work was to define a third-trimester HbA1c cut-off point for increased risk of fetal morbidity, macrosomia and LGA newborns.Methodology: Observational retrospective study of all singleton pregnant women with GDM, followed at our Diabetes and Pregnancy Clinic b...

ea0063gp221 | Gestational and Type 1 Diabetes | ECE2019

Insulin requirements during lactation in women with diabetes mellitus type 1 in comparison with pre-pregnancy levels – a retrospective study

Kakoulidis Ioannis , Ilias Ioannis , Linardi Anastasia , Michou Aikaterini , Milionis Charalampos , Lekkou Anastasia , Venaki Evangelia , Koukkou Eftychia

Introduction: Lactation is a period of particular importance regarding the management of glycemia in women with Diabetes Mellitus type 1 (DM1), the aim being to prevent hypoglycemia during breastfeeding. The purpose of this study was to investigate the variation of insulin requirements during lactation in comparison with pre-pregnancy levels in women with DM1 and to find potential correlation factors.Materials-methods: We conducted a retrospective case f...

ea0063gp222 | Gestational and Type 1 Diabetes | ECE2019

The impact of gestational weight gain on subclinical atherosclerosis, placental circulation and neonatal complications

Shargorodsky Marina , Barda Guilia

Objective: Vascular atherosclerotic changes, mediated by environmental and genetic factors, develop years before an event. Detection of vascular damage, using ultrasonographic measurement of carotid IMT, is predictive of future cardiovascular events. The present study was designed to investigate the impact of gestational weight gain (GWG) on early atherosclerotic changes during late pregnancy, using intima media thickness (IMT), as well as placental vascular circulation and in...