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21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

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18-21 May 2019, Lyon, France

Guided Posters

Metabolic Syndrome and Hypoglycaemia

ea0063gp38 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Beta cell senescence: effect of glucotoxicity and glucolipotoxicity

Kim Mi-kyung , Jung Hye Sook , Jang Jeong Eun , Kim Tae Nyun , Kwon Min Jeong , Lee Soon Hee , Rhee Byung Doo , Park Jeong Hyun

Pancreatic beta cell senescence is one of the recent explanations for theincreased prevalence of type 2 diabetes in the elderly. Aging may exert a distinct influence on pancreatic β cell turnover, regeneration capacity and function. Oxidative stresses induced by metabolic stresses reduce pancreatic beta cell mass and secretion. We investigated how metabolic stresses effect on pancreatic beta cell senescence. INS-1 cells were exposed to 33mM glucose (glucotoxicity: high gl...

ea0063gp39 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Generalized lipodystrophy associated with delayed neuro-somatic development and multiple dysmorphisms in a neonate with a compound heterozygous missense mutation in the SYNE2 gene

Pelosini Caterina , Ceccarini Giovanni , Aretini Paolo , Lorenzoni Francesca , Magno Silvia , Caligo Maria Adelaide , Sessa Maria Rita , Ferrari Federica , Ghirri Paolo , Santini Ferruccio

Generalized lipodystrophies are extremely rare diseases. Despite remarkable progress in identifying genes responsible for the most common forms of genetic lipodystrophies, the molecular basis of disease in some patients with distinctive phenotypes remains unclear. We herein describe the case of a male patient born from non-consanguineous parent affected by a syndrome characterized by generalized lipodystrophy, psycho-somatic growth retardation, cleft palate, macroglossia, righ...

ea0063gp40 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Long-term administration of Empagliflozin may promote hepatic and renal lipid accumulation, and inflammation in the APOE knockout model

Tsara Anna , Nasiri-Ansari Narjes , Dimitriadis Georgios K , Theocharis Stamatis , Karapanagioti1 Angeliki , Danas Eougken , Papavassiliou Athanasios G , Randeva Harpal S , Kassi Eva

Introduction: Metabolic disorders characterized by insulin resistance/hyperinsulinemia, such as metabolic syndrome and T2DM, are associated with Non-Alcoholic Fatty Liver Disease (NAFLD). SGLT-2i reduce reabsorption of glucose from the kidneys thereby promoting glucosuria, while their beneficial effects on insulin resistance have been recently recognized. In this study, we aimed to investigate the effect of Empagliflozin, in de novo triglyceride synthesis and beta-oxi...

ea0063gp41 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Applying the Bradford Hill criteria to evaluate the association between hypoglycaemia and cardiovascular events/mortality (CVEM) [Data from meta-analysis (MA), Randomized Controlled Trials (RCTs), and observational outcome studies (OBS)]

Farahani Pendar

Background: The association between hypoglycaemia and CVEM is controversial. It is not ethical or practical to design RCTs to study this association as the primary clinical outcome measure. Therefore, utilization of epidemiological principles to study this association is essential.Objective: To systematically explore the data from MA, RCTs and OBS on hypoglycaemia and CVEM applying Bradford Hill criteria [strength, consistency, dose response or biologica...

ea0063gp42 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Magnitude of effects of testosterone replacement therapy on testosterone normalization, parameters of metabolic syndrome and vascular function and morphology in obese hypogonadal patients with type 2 diabetes – the SETH2 study

Groti Antonic Kristina

Background: The association between testosterone deficiency, metabolic syndrome (MetS) and type 2 diabetes (T2DM) is well established. Male hypogonadism is related to an increase in glycometabolic and cardiometabolic complications.Objective: To evaluate magnitude of effects of testosterone replacement therapy (TRT) on testosterone normalization, parameters of the MetS and vascular function and morphology in obese hypogonadal male patients with T2DM.<...

ea0063gp43 | Metabolic Syndrome and Hypoglycaemia | ECE2019

The elevated chemerin plasma concentrations in men diagnosed with metabolic syndrome are correlated with markers of low-grade state inflammation but not with SHBG serum levels and accompanying hypoandrogenemia.

Herman Waldemar , Jarecki Piotr , Kołodziejczak Barbara , Wojcicka Marlena , Losy Jacek , Łęcka Katarzyna

Background: Chemerin (CHEM) is a newly-discovered adipokine involved in the immune, metabolic and reproductive processes. Low-grade state inflammation (LGSI) is a key element in the pathogenesis of metabolic syndrome (MS).Objectives: The aim of the study was to assess the effect of age on MS prevalence, androgenic status as well as on selected inflammatory indices and CHEM plasma concentrations. Additionally we investigated correlations between CHEM and ...

ea0063gp44 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Effects of anti-inflammatory treatment on fibroblast growth factor-21 in obesity and metabolic syndrome

Ebrahimi Fahim , Urwyler Sandrine , Betz Matthias , Christ Emanuel , Schuetz Philipp , Mueller Beat , Donath Marc , Mirjam Christ-Crain

Background: Fibroblast growth factor-21 (FGF21), which has recently been identified as a central regulator of metabolism, is known to be increased in conditions of obesity, insulin resistance, and fatty liver. Likewise, there is evidence that FGF21 increases with systemic inflammation. The aim of this study was to evaluate whether chronic low-grade inflammation might be the underlying mechanism and whether an anti-inflammatory treatment decreases FGF21 levels in metabolic diso...

ea0063gp45 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Hypoglycemia and dementia risk in older patients with type 2 diabetes: a propensity-score matched analysis of a population-based cohort study

Jin Han Seung , Kim Young-Gun , Young Moon So

Background: Type 2 diabetes mellitus (T2DM) is associated with an increased risk for dementia. The effects of hypoglycemia on dementia are controversial. Thus, we evaluated whether hypoglycemia increases the risk for dementia in senior patients with T2DM.Methods: We used the Korean National Health Insurance Service Senior cohort, which includes >10% of the entire senior population of South Korea. In total, 7,752 patients who had ever experienced hypo...

ea0063gp46 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Characteristics and management of Type 1 diabetes mellitus patients with diabetic ketoacidosis

Ling Ong Yan , Jye Seow Cherng

Background & Objectives: Type 1 diabetes mellitus (T1DM) is a complex disease with both genetic and environmental factors in its pathophysiology. Higher risks of diabetic emergencies such as diabetic ketoacidosis (DKA) confers a greater difficulty in its management than Type 2 diabetes. This study aims to describe and compare the characteristics, management and outcomes of T1DM patients with and without complication of DKA.Methods: A total of 333 T1D...

ea0063gp47 | Metabolic Syndrome and Hypoglycaemia | ECE2019

Awareness, treatment rates and compliance to treatment in patients with serum LDL cholesterol higher than 250 mg/dL, and possible, probable and definite familial hypercholesterolemia

Yaman Samet , Ozdemir Didem , Tugce Akman Busra , Cakir Bekir , Ersoy Osman

Aim: Familial hypercholesterolemia (FH) is an autosomal dominant genetic disease characterized by increased levels of low density lipoprotein cholesterol (LDL-chol). Despite relatively high prevalance and significant association with increased mortality, the awareness of physicians and patients is low and it is an underdiagnosed and undertreated disease. We aimed to detect patients with FH and determine treatment status and compliance.Materials and metho...