Searchable abstracts of presentations at key conferences in endocrinology
Previous issue | Volume 63 | ECE2019 | Next issue

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

Card image cap
18-21 May 2019, Lyon, France

ea0063oc5.1 | Adrenal 1 | ECE2019

Positive impact of genetic test on the management and outcome of patients with paraganglioma and/or pheochromocytoma

Buffet Alexandre , Aim Laurene Ben , Leboulleux Sophie , Drui Delphine , Vezzosi Delphine , Libe Rossella , Ajzenberg Christiane , Bernardeschi Daniele , Cariou Bertrand , Chabolle Frederic , Chabre Olivier , Darrouzet Vincent , Delemer Brigitte , Desailloud Rachel , Goichot Bernard , Esvant Annabelle , Offredo Lucile , Herman Philippe , Laboureau Sandrine , Lefebvre Herve , Pierre Peggy , Raingeard Isabelle , Reznik Yves , Sadoul Jean-Louis , Hadoux Julien , Tabarin Antoine , Tauveron Igor , Zenaty Delphine , Favier Judith , Bertherat Jerome , Baudin Eric , Amar Laurence , Gimenez-Roqueplo Anne-Paule

Context: Paragangliomas and pheochromocytomas (PPGL) are rare neuroendocrine tumors, characterized by a strong genetic component. Indeed, up to 40% of patients carry a germline mutation in a PPGL susceptibility gene. In accordance with the international recommendations, genotyping of PPGL susceptibility genes is therefore proposed to all patients with PPGL, but it has actually never been shown whether the identification of a germline mutation in one PPGL susceptibility gene ch...

ea0063oc5.2 | Adrenal 1 | ECE2019

Pheochromocytoma aggressiveness induced by tumor microenvironment depends on the SDH subunit involved

Martinelli Serena , Riverso Maria , Mello Tommaso , De Filpo Giuseppina , Canu Letizia , Maggi Mario , Mannelli Massimo , Rapizzi Elena

Pheochromocytoma/paraganglioma (Pheo/PGL) are rare neuroendocrine tumors generally benign. About 30–40% of Pheo/PGL are due to germ-line mutations in one of the susceptibility genes, including those encoding the succinate dehydrogenase subunits A-D (SDHA-D). Up to 80% of patients affected by SDHB mutated Pheo/PGL develop metastatic disease with no successful cure at present. In this study, we evaluated the different effect of tumor microenvironment on tu...

ea0063oc5.3 | Adrenal 1 | ECE2019

SF3B1 as novel target for the treatment of multiple endocrine-related cancers

Jimenez-Vacas Juan M , Lopez-Canovas Juan L , Vazquez-Borrego Mari C , Pedraza-Arevalo Sergio , del Rio-Moreno Mercedes , Herrero-Aguayo Vicente , Saez-Martinez Prudencio , Montero-Hidalgo Antonio J , Encinas Ricardo Blazquez , Lara-Lopez Araceli , Perez-Gomez Jesus M , Gomez-Gomez Enrique , Herrera-Martinez Aura , Gadelha Monica R , Castano Justo P , Gahete Manuel D , Luque Raul M

The intrinsic heterogeneity of endocrine-related cancers (ERCs) hampers the identification and development of global and effective therapeutic treatments for these pathologies. However, the dysregulation of the splicing process has been postulated as a new common hallmark shared by most cancer types, since it is associated with the appearance of splicing variants with oncogenic potential (e.g. CD44v6, BCL-Xs, AR-v7, SST5TMD4, In1-ghrelin...

ea0063oc5.4 | Adrenal 1 | ECE2019

The splicing factor NOVA1 is overexpressed in pancreatic neuroendocrine tumors and related to increased aggressiveness and malignancy

Pedraza-Arevalo Sergio , Alors-Perez Emilia , Herrera-Martinez Aura D. , Blazquez-Encinas Ricardo , Sanchez-Sanchez Rafael , Ortega-Salas Rosa , Serrano-Blanch Raquel , Gahete Manuel D. , Luque Raul M , Castano Justo P

There is increasing evidence that alterations in alternative splicing can be linked to key tumor features in cancer. Dysregulations in the splicing machinery constitute the underlying cause in many of these alterations and, consequently, splicing and its control are emerging as a novel and transversal cancer hallmark, due to its association with different dysfunctions of tumor cells. In line with this, we discovered the existence of aberrantly spliced variants of somatostatin ...

ea0063oc5.5 | Adrenal 1 | ECE2019

Impact of adrenal insufficiency on patient-centred health care outcomes in adult medical inpatients

Widmer Andrea , Ebrahimi Fahim , Wagner Ulrich , Mueller Beat , Schuetz Philipp , Christ-Crain Mirjam , Kutz Alexander

Background: Patients with adrenal insufficiency suffer from increased morbidity and mortality. Quantitative evidence on the health-care burden of either primary (PAI) or secondary adrenal insufficiency (SAI) among hospitalized medical patients is scarce.Methods: In this observational cohort study, we analysed nationwide acute care hospitalizations from patients with PAI or SAI, respectively, between 2011 and 2015 using prospective administrative data. Pa...