Endocrine Abstracts

Background and objective: According to recent studies, endocrine societies have modified the treatment criteria of subclinical gestational hypothyroidism, increasing TSH upper-limit value commonly set at 2.5 μU/ml to a new threshold set at 4 μU/ml. This change in criteria has responded to numerous studies which seem to indicate that the obstetrical complications do not generally increase despite this variation of the threshold TSH value. A further discussion lays now...

Background: Thyroid dysfunction is associated with increased cardiovascular morbidity and mortality. Early detection may influence the clinical management of the patients. There is insufficient data about the prevalence and clinical significance of thyroid dysfunction in cardiovascular hospitalized patients.Aims: To study the prevalence of thyroid dysfunction in cardiovascular hospitalized patients, to characterize patients with high prevalence of thyroi...

Background/objective: mETE has shown no effect on survival, and the 8th edition of the AJCC classification no longer considers mETE in the pT3 definition. Therefore, tumors with mETE below 40 mm are now staged pT1/pT2. However, controversy remains regarding mETE impact on disease recurrence. This study assessed the risk of recurrence of PTC patients previously classified as pT3 because of mETE, compared to PTC patients staged pT1-pT2.Methods: Monocentric...

Introduction: The syndrome of reduced sensitivity to thyroid hormone (SRSTH) due to mutations of thyroid hormone receptor β (TRB) consists of an inappropriate secretion of TSH with elevated levels of thyroid hormones. Cardiovascular manifestations are often the ones that affect patients. Our aim was to evaluate the cardiac and vascular characteristics of patients with SRSTH due to TRB mutations.Materials and methods: We analysed cl...

Background: Accumulating evidence indicates the presence of bidirectional cross-talks between the endocrine and the immune system. However, no data are available on the influence of either the thyroid hormones or TSH within the normal range on the immune cell function in healthy humans.Aim: To comprehensively investigate the effects of the hypothalamic-pituitary-thyroid axis on the variation of immune responses in a cohort of healthy volunteers.<p cl...