Endocrine Abstracts

Background: Early screening and the treatment of glucose metabolism disorders could lower the risk of further complications. For this purpose it is important to identify the risk factors of type 2 diabetes mellitus (T2DM). The aim of this study was to determine the association between various hormonal factors and the risk of incident type 2 diabetes in the large prospective female E3N cohort study.Material and methods: The study included 83,799 French wo...

Human sex hormone-binding globulin (SHBG) is produced by the liver and secreted it into the circulation where it binds androgens and estrogens with high affinity. Therefore, SHBG acts as a carrier of these sex steroids and regulates their bioavailability. Low plasma SHBG levels are associated with obesity, fatty liver disease, abdominal adiposity and metabolic syndrome, and predict the development of type 2 diabetes. In addition, an inverse relationship between plasma SHBG lev...

Aims: Meteorin-like (Metrnl) was recently identified as a novel adipomyokine induced by exercise and cold exposure. Metrnl improves glucose tolerance, increases systemic energy expenditure, induces white adipose browning, and promotes anti-inflammatory gene programs in obese/diabetic mice. However, the relationship of Metrnl with diabetes and cardiometabolic risk variables in humans has not been explored.Methods: In 800 subjects (400 patients with type 2...

Background and aims: Diabetic kidney disease (DKD) is a common microvascular complication that affects 40% of patients with diabetes mellitus (DM). Emerging evidence suggests a role for microRNAs (miRNAs) in the development of DKD. In this context, miR-15a-5p and miR-30e-5p have been shown to regulate the expression of the uncoupling protein 2, a mitochondrial protein that decreases reactive oxygen species (ROS) formation by mitochondria. Since ROS overproduction is a key cont...

Introduction: Diabetes mellitus (DM) is a chronic disease associated with multi-organ complications, including poor bone quality and high risk of frailty fracture. Bone and vascular complications seemed to be connected, as diabetic patients with atherosclerotic lesions show enhanced extrascheletric calcifications which in turn are associated with increased fracture risk. The aim of this study was to assessed bone mineral density (BMD) and trabecular bone score (TBS) in diabeti...