Endocrine Abstracts

A link between thyroid function and psychiatric illness, particularly major depressive disorder (MDD) is well established. Hypothyroidism has been shown to render patients more susceptible to MDD and less responsive to antidepressant drugs. Triiodothyronine (T3) has been shown to enhance antidepressant response in euthyroid patients who have not responded to standard antidepressant treatment. Furthermore, concurrent treatment with T3 may enhance and possibly accelerate treatme...

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Our group studies the influence of different endocrine factors on cardiovascular function. Ang II is the main vasopeptide of Renin-Angiotensin System (RAS) and exerts its potent biological effects through AT1 and AT2 receptors. In heart, Ang II induces cardiomyocyte hypertrophy and fibroblast hyperplasia through TGF-β1 recruitment. On the other hand, cardiovascular system is very sensitive to the action of the Thyroid Hormones (THs). One major cardiovascular manifestation...