Menstrual disorders are common during adolescence. In many cases menstrual disorders associated with endocrine violations.
Objective: To study the frequency menstrual disorders and endocrine violations in adolescent girls.
Patients and methods: The study included 2527 adolescents- schoolgirls (aged 1217 years, mean age was 15.5±1.9 years). The main outcome measures were menstrual disorders. Adolescent girls without menstrual disorders formed the control group (n=50). A full clinical examination, hormonal analysis and thyroid and pelvic ultrasound examination were conducted. This study was carried out in accordance with the Helsinki Declaration. Data was analyzed using SPSS Statistics v 18.104.22.168. Data was compared using chi-square test and P ≤ 0.05 was regarded as statistically significant.
Results: The median age of menarche in this investigation is 12.3 years. Dysmenorrhea and oligomenorrhea were the most common menstrual disorders in girls. The prevalence of dysmenorrhea was 62%. In girls with dysmenorrhea in 1% cases was diagnosed hyperprolactinemia, in 20% inflammation of genitals and in 30%- ovarian cysts. Among the girls with dysmenorrhea thyroid diseases (endemic goiter) were revealed in 73% cases. Oligomenorrhea was diagnosed in 22% adolescent girls and was associated in 80% cases with hirsutism. The investigation showed that in 5 girls with oligomenorrhea and hirsutism was diagnosed nonclassic congenital adrenal hyperplasia due to P450c21 (21-hydroxylase deficiency), 18 girls had polycystic ovary syndrome. Pelvic ultrasound examination established that 65% patients with oligomenorrhea and hirsutism had multifollicular ovaries. In the control group thyroid diseases (endemic goiter) was diagnosed in 20% adolescent girls, hirsutism in 1% and multifollicular ovaries in 8% girls (P<0.01)
Conclusions: This study demonstrates a high frequency of menstrual disorders in adolescent girls. Dysmenorrhea associated with hyperprolactinemia, ovarian cysts and thyroid diseases, oligomenorrhea associated with nonclassic congenital adrenal hyperplasia, polycystic ovary syndrome and multifollicular ovaries.
18 - 21 May 2019
European Society of Endocrinology