ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P605 | DOI: 10.1530/endoabs.63.P605

Parabens and their relationship to obesity

Monika Šrámková1,2,3, Lucie Kolátorová3, Jana Vítků3, Josef Včelák3, Olga Lischkova3, Luboslav Stárka3 & Michaela Dušková3

1Motol University Hospital, Prague, Czech Republic; 2First Faculty of Medicine of Charles University, Prague, Czech Republic; 3Institute of Endocrinology, Prague, Czech Republic.

Introduction: Parabens are a group of chemicals used as preservatives in the food, cosmetic and pharmaceutical industries. They are known to possess estrogenic effects, and therefore have been classified as endocrine disruptors. In addition to the classical endocrine organs, other tissues have endocrine activity, including adipose tissue. Several chemicals are known to cause obesogenic effects, and parabens are currently being studied in this context. The aim of this study was to investigate the possible connections of paraben exposure and obesity.

Methods: Our study included 27 healthy women with regular menstrual cycle. Basal anthropometric measures, levels of parabens (methylparaben, ethylparaben and propylparaben), adipokines (adiponectin, adipsin, leptin, resistin and visfatin) and hormones affecting energy balance and metabolic health (c-peptide, ghreline, GIP, GLP-1, glucagon, insulin, PAI-1) were measured.

Results: A Kolmogorov-Smirnov test showed higher methylparaben and propylparaben levels in women with BMI 25–34.9 compared to those with 18.5–24.9. Plasma levels of methylparaben as well as the sum of parabens were positively associated with the plasma adipsin levels. Negative associations for methylparaben were found for glucagon, leptin and PAI-1.

Conclusion: In accordance with other experimental studies we observed important associations of methylparaben and hormones affecting energy balance and metabolic health, indicating its obesogenic potential. This study highlights that the usage of parabens in varios food, cosmetic and pharmaceutic products may be connected not only with hormone dependent health problems but also with diseases of civilization like obesity.

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