Endocrine Abstracts

Introduction: Vitamin D is essential for calcium metabolism and is involved in bone turnover. The purpose of this study was to examine vitamin D status and its relation with bone metabolism in adult patients with T1DM.

Methods/Design: We studied 118 patients with T1DM (Group-D) (mean age: 35.4+10.3 years) and 94 healthy controls (Group-C) matched for age, sex and body mass index (BMI). In both groups HbA1c, 25(OH)Vitamin D (Vit-D), serum calcium (Ca), phosphorus (Ph), magnesium (Mg), alkaline phosphatase (ALP), albumin (alb), parathyroid hormone levels (PTH), β-crosslaps, type 1 procollagen total N-terminal propeptide (TP1NP) were measured. Vit-D levels 30–50 ng/ml were defined as optimal concentration (OC), 20–30 ng/ml as suboptimal concentration (SC), 10–20 ng/ml as deficiency (DE) and 0–10 ng/ml as insufficiency (IN).

Results: In Group-D, mean duration of DM was 16.2+9.5 years and mean HbA1c was 7.8+1.4%. In Group-D, Vit-D OC occurred in 20%, SC occurred in 27.1%, DE occurred in 34.3%, with the remaining 18.6% having a Vit-D level below 10 ng/m(IN). In Group-C, Vit-D OC occurred in 23.4%, SC occurred in 31.6%, DE occurred in 28.4%, with the remaining 16.6% having a Vit-D level below 10 ng/ml (IN). The overall mean Vit-D levels were not significantly different between groups (D: 20.4+11.0 vs C: 21.2+8.4, P=0.743). Also, Ca, Ph, Mg, ALP and PTH levels were comparable in both groups. B-crosslaps were significant lower in Group-D compared to control (D: 325.7+198.9 vs C: 442.8+220.6, P=0.002) but TP1NP were lower in Group-D but not statistical significant (D: 50.34+30.97 vs C: 53.12+24.43, P=0.594). In T1DM patients, no correlation was found between Vit-D and HbA1c (r=0.032, P=0.794), Vit-D and β-crosslaps (r=−0.004, P=0.976) and Vit-D and TP1NP (r=0.009, P=0.944).

Conclusion: These data suggest that Vit-D and calcium metabolism in patients with T1DM were comparable with the controls and were not correlated with glycemic control and bone metabolism.