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Endocrine Abstracts (2019) 63 P614 | DOI: 10.1530/endoabs.63.P614

ECE2019 Poster Presentations Diabetes, Obesity and Metabolism 2 (100 abstracts)

Vitamin D status and bone metabolism in adult patients with Type 1 diabetes mellitus

Eleftheria Barmpa 1 , Spyros Karamagiolis 2 , Stelios Tigas 3 , Georgios N Koukoulis 1 & Alexandra Bargiota 1


1Department of Endocrinology and Metabolic Diseases, University of Thessaly, Larissa, Greece; 2General Hospital, Larissa, Greece; 3Department of Endocrinology, University of Ioannina, Ioannina, Greece.

Introduction: Vitamin D is essential for calcium metabolism and is involved in bone turnover. The purpose of this study was to examine vitamin D status and its relation with bone metabolism in adult patients with T1DM.

Methods/Design: We studied 118 patients with T1DM (Group-D) (mean age: 35.4+10.3 years) and 94 healthy controls (Group-C) matched for age, sex and body mass index (BMI). In both groups HbA1c, 25(OH)Vitamin D (Vit-D), serum calcium (Ca), phosphorus (Ph), magnesium (Mg), alkaline phosphatase (ALP), albumin (alb), parathyroid hormone levels (PTH), β-crosslaps, type 1 procollagen total N-terminal propeptide (TP1NP) were measured. Vit-D levels 30–50 ng/ml were defined as optimal concentration (OC), 20–30 ng/ml as suboptimal concentration (SC), 10–20 ng/ml as deficiency (DE) and 0–10 ng/ml as insufficiency (IN).

Results: In Group-D, mean duration of DM was 16.2+9.5 years and mean HbA1c was 7.8+1.4%. In Group-D, Vit-D OC occurred in 20%, SC occurred in 27.1%, DE occurred in 34.3%, with the remaining 18.6% having a Vit-D level below 10 ng/m(IN). In Group-C, Vit-D OC occurred in 23.4%, SC occurred in 31.6%, DE occurred in 28.4%, with the remaining 16.6% having a Vit-D level below 10 ng/ml (IN). The overall mean Vit-D levels were not significantly different between groups (D: 20.4+11.0 vs C: 21.2+8.4, P=0.743). Also, Ca, Ph, Mg, ALP and PTH levels were comparable in both groups. B-crosslaps were significant lower in Group-D compared to control (D: 325.7+198.9 vs C: 442.8+220.6, P=0.002) but TP1NP were lower in Group-D but not statistical significant (D: 50.34+30.97 vs C: 53.12+24.43, P=0.594). In T1DM patients, no correlation was found between Vit-D and HbA1c (r=0.032, P=0.794), Vit-D and β-crosslaps (r=−0.004, P=0.976) and Vit-D and TP1NP (r=0.009, P=0.944).

Conclusion: These data suggest that Vit-D and calcium metabolism in patients with T1DM were comparable with the controls and were not correlated with glycemic control and bone metabolism.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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