ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 GP201 | DOI: 10.1530/endoabs.63.GP201

Blood intact incretin levels are related to beta-cell function and glycemia in patients with type 2 diabetes

Yeekyoung Ko1, Soyeon Yoo1,2 & Gwanpyo Koh1,2

1Department of Internal Medicine, Jeju National University Hospital, Jeju, Republic of Korea; 2Department of Internal Medicine, Jeju National University School of Medicine, Jeju, Republic of Korea.

We performed this study to identify factors related to intact incretin levels in patients with type 2 diabetes (T2D). We cross-sectionally analyzed 336 patients with T2D. Intact glucagon-like peptide 1 (iGLP-1) and intact glucose-dependent insulinotropic polypeptide (iGIP) levels were measured in a fasted state and 30 min after ingestion of a standard mixed meal. The differences between 30 and 0 min iGLP-1 and iGIP levels were indicated as ΔiGLP-1 and ΔiGIP. After ingestion of a mixed meal, iGLP-1 (5.5±3.0 to 10.4±7.0 pmol/l; P<0.001) and iGIP (3.8±3.8 to 21.5±7.1 pmol/l; P<0.001) levels increased by 190% and 570%, respectively. In simple correlation analyses, fasting iGLP-1 was positively correlated with glucose (r=0.199; P<0.001), C-peptide (r=0.137; P<0.05), creatinine (r=0.124; P<0.05) and triglyceride (r=0.112; P<0.05) levels, and negatively correlated with eGFR (r=−0.139; P<0.05). ΔiGLP-1 was positively correlated only with ΔC-peptide levels (r=0.194; P<0.001). Fasting iGIP showed positive correlations with HbA1c (r=0.146; P<0.01), fasting glucose (r=0.126; P<0.05) and C-peptide (r=0.153; P<0.01) levels, and negative correlations with ΔC-peptide (r=−0.183; P<0.01) and HDL cholesterol (r=−0.124; P<0.05) levels. ΔiGIP was negatively correlated with diabetes duration (r=−0.118; P<0.05) and HbA1c (r=−0.196; P<0.001) levels, and positively correlated with ΔGlucose (r=0.210; P<0.001) and ΔC-peptide (r=0.238; P<0.01) levels. In multivariate analyses adjusting for age, sex, and covariates, fasting iGLP-1 levels were significantly related to fasting glucose (β=0.189, P<0.01) and creatinine (β=0.158, P<0.05) levels, ΔiGLP-1 levels were positively related to ΔC-peptide levels (β=0.194, P<0.001), fasting iGIP levels were related to fasting C-peptide levels (β=0.160, P<0.01) and female sex (β=0.124, P<0.05), and ΔiGIP levels were positively related to ΔC-peptide (β=0.165, P<0.01) and Δglucose (β=0.138, P<0.05) levels. Taken together, intact incretin levels are primarily related to C-peptide and glucose levels. This result suggests that glycemia and insulin secretion are the main factors associated with intact incretin levels in T2D patients.

Article tools

My recent searches

No recent searches.