Causing production of free radicals and reduction of antioxidant system activity, in the pancreatic β-cells, in particular, resulting in reduction in insulin production and consequently to hyperglycemia, oxidative stress could be a pathogenetic mechanism of morbidity in diabetes mellitus. Search for and development of medicines with antioxidant and hypoglycemic activity remains urgent.
Aim: The work was initiated to study antioxidant and hypoglycemic effects of gossitan.
Materials and methods: Produced from the polyphenol compounds isolated from the upland cotton (Gossypium hirsutum L) gossitan is a medicine with interferon-producing and antiviral effects effective against various influenza strains. Antioxidant effects of gossitan were examined in the models of adrenalin autoxidation and ascorbate-dependent lipid peroxidation. Experimental diabetes mellitus was induced by three-fold intraperitoneal administration of diabetogenic doses of alloxan. Gossitan was administered intragastrically in the dose of 4.9 mg/kg within 10 days until blood glucose was 11 mmol/l. Quercetine, a polyphenol, and gliclazide, were used as the controls.
Results: Gossitan was found to cause reduction in adrenaline oxidation by 35.7%, while quercetine reduced it by 37.7%, and twofold reduction in malondialdehyde in the liver homogenate of rats with experimental diabetes mellitus. Per oral administration of gossitan to the rats was found to decrease their blood glucose by 43.6%.
Conclusions: A polyphenol-based medicine, gossitan was found to possess antioxidant activity similar to the one of quercetine and to facilitate blood glucose decrease in rats with experimental diabetes mellitus, which seems to be associated with partial restoration of glucokinase activity in the rat liver and insulin level.
18 - 21 May 2019
European Society of Endocrinology