Aims: To assess the relationship between sleep quality and fear of hypoglycemia, glycemic variability and other diabetes-related outcomes in type 1 diabetes.
Methods: Our data were provided by the VARDIA Study, a multicentric observational cross-sectional study conducted between June and December 2015. Sleep characteristics were assessed by Pittsburgh Sleep Quality Index (PQ1I). Fear of hypoglycemia was measured with the Hypoglycemia Fear Survey version II (HFS-II). Glycemic variability was determined using the CV of three 7-points self-monitoring blood glucose profiles and the mean amplitude of glycemic excursion (MAGE). Comparisons between good (PQ1I≤5) and poor (PQ1I>5) sleepers and correlation between PQ1I and these different parameters were tested.
Results: 315 patients were eligible for PQ1I questionnaire analysis: 54% women, mean age 47±15 years old, mean diabetes duration of 24±13 years, HbA1c of 7.6±0.9% (60±7.5 mmol/mol). Average PQ1I score was 6.0±3.3 and 59.8% of the patients had a total PQ1I score >5. HFS-II score was significantly higher among patients with sleep disturbances (P<0.0001) and global PQ1I score was positively correlated with HFS-II (β=0.19; 95% CI=0.07;0.30). GV evaluated by CV or MAGE did not differ between poor and good sleepers (P=0.28 and 0.54, respectively).
Conclusions: Adult patients with type 1 diabetes have disturbed sleep quality which correlate with fear of hypoglycemia. This study suggests that fear of hypoglycemia is a target for intervention to improve sleep quality in adults with type 1 diabetes.
18 - 21 May 2019
European Society of Endocrinology