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Endocrine Abstracts (2019) 63 GP259 | DOI: 10.1530/endoabs.63.GP259

ECE2019 Guided Posters Thyroid Nodules and Cancer 2 (11 abstracts)

Sentinel lymph node biopsy using methylene blue dye in clinically N0 papillary and medullary thyroid carcinomas for decision on one-time lateral neck dissection

Nada Santrac 1 , Ivan Markovic 1, , Merima Goran 1, , Marko Buta 1, , Gordana Pupic 3 & Radan Dzodic 1,


1Surgical Oncology Clinic, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia; 2Medical Faculty, University of Belgrade, Belgrade, Serbia; 3Department of Pathology, Institute for Oncology and Radiology of Serbia, Belgrade, Serbia.

Introduction: Surgical management of clinically N0 (cN0) patients with thyroid carcinomas remains debatable due to various reported frequencies of lymph node (LN) metastases. The aim of this paper was to present usefulness of sentinel lymph node biopsy (SLNB) of jugulo-carotid regions after methylene blue dye (MBD) mapping in intraoperative selection of cN0 patients with papillary and medullary thyroid carcinomas for one-time lateral neck dissection (LND).

Materials & methods: We present results of three studies from our Surgical Oncology Clinic that analyzed usefulness of Dzodic’s original SLNB method for LN staging in thyroid carcinomas (published in Word J Surg, 2006): the first with 153 cN0 papillary thyroid carcinomas (PTC), the second with 111 cN0 micro-PTCs and the third with 17 cN0 medullary thyroid microcarcinomas (micro-MTC) with serum calcitonin levels <1000 pg/ml. All patients underwent injection of 1%-MBD subcapsullary in both lobes, total thyroidectomy, prophylactic central neck dissection and SLNB of jugulo-carotid regions. All sentinel-LNs were examined by frozen section analysis (FSA). One-time LND was performed only in patients with sentinel-LN metastases on FSA. Otherwise, surgery was not extended.

Results: None of the patients had allergic reactions to MBD. LN metastases were histologically verified in 40.9% of cN0 PTCs and 25% of cN0 micro-PTCs. Only one patient with hereditary micro-MTC had LN metastases in central and both lateral regions. Dzodic’s SLNB method enabled detection of LN metastases in lateral neck compartments in 21% of patients. Skip metastases were detected in about 4% of patients with PTCs and micro-PTCs, while there were no skip metastases in micro-MTCs. Method’s overall accuracy was high in all studies, but the highest in the study with micro-MTCs (100%).

Conclusion: Dzodic’s SLNB method with MBD mapping and FSA of sentinel-LNs from jugulo-carotid regions is accurate in detection of lateral LN metastases in cN0 patients with papillary and medullary thyroid carcinomas and microcarcinomas. It prevents over-treatment of patients without metastases in sentinel-LNs and helps in decision for one-time LND in patients with histologically proven sentinel-LN metastases. This method additionally facilitates central neck dissection and diminishes the possibility of accidental removal of parathyroid glands (that remain non-colored), even in less experienced surgeons’ hands.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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