Objective: Apolipoprotein B/Apolipoprotein A-1 ratio (Apo B/Apo A-1) and lipoprotein (a) (Lp(a)) are known to be associated with atherosclerotic vascular disease. We investigated the influence of Apo B/Apo A-1 and Lp(a) on coronary artery calcification (CAC) among healthy Korean adults.
Methods: A total of 1081 participants underwent cardiac computed tomography in health promotion center were enrolled. Anthropometric profiles and multiple cardiovascular risk factors, including Apo B, Apo A-1, and Lp(a) were measured were measured. Multi-detector CT was used to measure coronary artery calcium score (CACS) and CACS>0 was defined as the presence of CAC. Adjusted Odds ratios for the presence of CAC according to Lp(a) and Apo B/Apo A-1 tertiles were estimated using logistic regression.
Results: Subjects were grouped according to Lp(a) and Apo B/Apo A-1 levels. There were significant differences in cardiovascular parameters among the groups and the prevalence of CAC significantly increased with Lp(a) and Apo B/Apo A-1 levels. In the logistic regression analysis adjusted for multiple risk factors, odds ratio (95% CI) for the prevalence of CAC comparing the lowest Lp(a) and Apo B/Apo A-1 group to the highest group was 2.554 (1.2565.201) (P<0.05).
Conclusion: These results show that Apo B/Apo A-1 and Lp(a) have a synergistic impact on prevalence of CAC, which suggests that individuals with elevated Lp(a) and Apo B/Apo A-1, should be more closely monitored to allow a better risk assessment for subclinical atherosclerosis.
18 - 21 May 2019
European Society of Endocrinology