ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P1097 | DOI: 10.1530/endoabs.63.P1097

Predictive factor of hypopituitarism in prolactinoma

Mouna Elleuch, Fatma Loukil, Fatma Mnif, Dhouha Ben Salah, Faten Hadjkacem, Mouna Mnif, Nedia Charfi, Nabila Rekik & Mohamed Abid


Endocrinology Hedi Chaker, Sfax, Tunisia.


Intoduction: Pitiutary tumor is considered as the first etiology responsable of secondary hypopituitarism. Hypogonadotropic hypogonadism is the most commonly reported lesion.

Meterials and methods: It is a retrospective study including 77 cases of prolactinoma. The data collection was done over 17 years, between 2000 and 2017.

Results: Gonadotropic deficiency was confirmed in 48 patients (63.6%). A significant negative correlation was found between prolactinoma size and LH level (r=−0.348 P=0.006). This correlation was present but not significant with the level of FSH. In men, a negative correlation was found between testosterone levels and prolactinoma size. In women, we did not show a correlation between estradiolemia and tumor size. Thyrotropic deficiency was confirmed in 18 patients (25.3%). The hormonal assessment confirmed the corticotropic deficit in 4 patients (4.2%). A total of 58 (75.3%) patients had dissociated hypopituitarism among which, 30 (51.7%) had isolated hormone deficiency, and 28 (48.2%) had 2 or 3 pituitary deficits.Gonadotropic deficiency was 3-fold greater than thyrotropic deficiency and 15-fold higher than corticotropic deficiency. A significant positive correlation was found between the tumor size and the number of deficits observed (P=0.000 and Pearson r=0.594).

Conclusion: It seams that prolactinoma size was the most important predictive factor influencing the appearance of hypopituitarisme. For that we must fight against the increase of the tumor size to avoid this complication.

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