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Endocrine Abstracts (2019) 63 P1144 | DOI: 10.1530/endoabs.63.P1144

ECE2019 Poster Presentations Reproductive Endocrinology 2 (39 abstracts)

The impact of vitamin D supplementation on HOMA IR and ovulation in patients with polycystic ovarian syndrome

Emir Muzurovic 1, & Snezana Vujosevic 1,

1Clinical center of Montenegro, Podgorica, Montenegro; 2Medical school University of Montenegro, Podgorica, Montenegro.

Introduction: Polycystic ovarian syndrome (PCOs) is a common cause of ovarian dysfunction in women with anovulation. Vitamin D plays a physiologic role in reproduction including ovarian follicular development and luteinization via altering anti-müllerian hormone (AMH) signalling, follicle-stimulating hormone sensitivity and progesterone production in human granulosa cells. Low vitamin D levels may exacerbate the symptoms of PCOS, including insulin resistance, ovulatory, menstrual irregularities, infertility, obesity and elevate the risk of cardiovascular diseases.

Aim: Aim of the study is to estimate the impact of vitamin D supplementation on insulin resistance, using HOMA IR calculation, in PCOs patients.

Materials and methods: The study includes 60 patients with PCOs and normal levels of vitamin D (between 50–100 ng/ml) divided in four groups. Before treatment, we measured fasting glucosae and insulin levels and calculate HOMA IR to all patients. Then we divided patients in four treatment groups: MD- treated with MET (metformin) plus LGD(low glycaemic diet-1800 Kcal), MDW- treated with MET plus LGD plus vitamin D supplementation 14000 ij/weekly, MDD2- treated with MET plus LGD plus vitamin D supplementation 2000 ij/daily and MDD4- treated with MET plus LGD plus vitamin D supplementation 4000 ij/daily. During period of six months we followed progesterone levels on 21th day of menstrual cycle. After six months of treatment we evaluated fasting glucosae, fasting insulin and HOMA IR.

Results: After treatment mean values of HOMA IR in MD group was reduced from 2.93±1.43 to 2.31±1.01(reduced for 21%), in MDW group was reduced from 2.84±0.93 to 2.30±1.22 (reduced for 19%), in MDD2 group was reduced from 2.89±1.21 to 2.19±1.44 (reduced for 24%) and in MDD4 group was reduced from 2.99±1.40 to 1.97±0.95(reduced for 34%) (P<0.05). Also number of biochemical confirmed ovulations, during six months of treatment, was the highest in MDD4 group, 2.45 ovulations per patients, then in MDD2 group, 1.61 ovulations/patients, while in the MD i MDW groups were similar 1.14 and 1.11 ovulation/patients.

Conclusion: In patients with metformin and diet treated polycystic ovarian syndrome, weekly supplementation with vitamin D have no additional effect on the reduction of insulin resistance. However, daily supplementation with vitamin D has a significant effect on the additional reduction of insulin resistance, especially at a dose of 4000 IU per day. Also, the same dose significantly improves ovulation in patients who are already treated with metformin and diet.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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