ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P1152 | DOI: 10.1530/endoabs.63.P1152

Effects of paroxitine on biochemical parameters and reproductive function in male rats

Rachid Mosbah1,2, Aziz Chettoum3, Zohir Djerrou4 & Alberto Mantovani5


1Department of Biology, University M’Hamed Bougara, Boumerdes, Algeria; 2Laboratory of Animal Eco-biology ENS- Kouba, Algiers, Algeria; 3ENS, University of Mentouri-, Constantine, Algeria; 4University of August 20th 1955, Skikda, Algeria; 5Department of Food Safety, Nutrition and Veterinary Public Health, Istituto Superiore di Sanità, Rome, Italy.


Selective serotonin reuptake inhibitors (SSRI) are a class of molecules used in treating depression, anxiety, and mood disorders. Paroxetine (PRT) is one of the mostly prescribed antidepressant which has attracted great attention regarding its side effects in recent years. This study was planned to assess the adverse effects of paroxitine on the biochemical parameters and reproductive system. Fourteen male wistar rats were randomly allocated into two groups (7 rats or each): control and treated with paroxitine at dose of 5 mg/kg.bw for two weeks. At the end of the experiment, blood was collected from retro orbital plexus for measuring the biochemical parameters, whereas the reproductive organs were removed for measuring semen quality and the histological investigations. Results showed that paroxitine induced significant changes in some biochemical parameters and alteration of semen quality including sperm count, spermatids number and sperm viability, motility and abnormalities. The histopathological examinations of testis and epididymis revealed an alteration of spermatogenesis, cellular disorganization and vacuolization, enlargement of interstitial space, shrinkage and degenerative changes in the epithelium of seminiferous and epididymal tubules with few to nil numbers of spermatozoa in their lumens. In conclusion, paroxitine treatment caused changes in some biochemical parameters and sperm profile as well as histopathologic effects in the reproductive organs.

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