ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P1193 | DOI: 10.1530/endoabs.63.P1193

Surgical outcome of thyroid nodules with atypia of undetermined significance in fine needle aspiration biopsy

Murat Karaoglan1, Rifat Emral2, Koray Ceyhan3, Murat Cinel2, Adile Begum Bahcecioglu2 & Demet Corapcioglu2


1Ankara University Department of Internal Medicine, Ankara, Turkey; 2Ankara University Departman of Endocrinology and Metabolism, Ankara, Turkey; 3Ankara University Department of Pathology, Ankara, Turkey.


Thyroid nodules have 3–7% freuquency in general population. FNA biopsy is an important diagnostic tool for patients with thyroid nodules. There are many reporting systems for FNA biopsy and Bethesda system is the most common one. The aim of this retrospective study, detect the atypia of undetermined significance (AUS) rates in the patients who performed FNA biopsy and evaluate the concomittant biopsy results of this patients and malignancy rates in the patients who were candidate and performed surgical operation. In this study 5958 patients who was performed thyroid FNAB between 2012 and 2017 in Ankara University Hospital evaluated retrospectively. Frequency of AUS has been found as 9.82%. When FNAB and final pathology results evaluate together and FNAB’s sensitivity is found as 50% and spesivity is 59.5%. The frequency of atypia of undetermined significance in patient series on the literatüre is between 3-10% and in our study we found this rate as 9.82%. The malignancy rates according to final pathology reports are between 22–35% and we found this rate as 52.5%. When the sample divided into three groups as 1) whose 1 fnab cytology result in AUS 2) whose 2 fnab cytology results in AUS, 3) whose 3 fnab cytology results in AUS, malignancy rates were 54%, 44% and 60%, respectively. There was no significant difference between the groups regarding the incidence of malignancy. This findings suggest that repeated FNABs have no predictive value in patients with AUS on thyroid cytopathology. New studies with larger patients series is necesary about this topic. In this study no significant relationship was found between preoperative sonographic features and malignancy risk in patients with AUS on thyroid cytopathology.

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