ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P123 | DOI: 10.1530/endoabs.63.P123

Effects of lemon and cumin on premature atherosclerosis in obese patients

Randa Salam1, Mary Fawzy1, Rehab Gab Alla2, Samah Sayed3, Seham Mahmoud3 & Ashraf Abd El Megid3

1Cairo Unversity, Cairo, Egypt; 2Agriculture Research Center, Cairo, Egypt; 3Helwan, Cairo, Egypt.

Background: Obesity is a multifactorial chronic disease that leads to a cardio-metabolic disease, with increased incidence of atherosclerosis.

Aim: Our aim to evaluate premature atherosclerosis in those patient and the impact of different diet on ameliorating its course.

Methodology: 100 obese patients were subjected to Hb A1c, Fasting blood glucose, lipid profile, carotid artery duplex, and Brachial artery flow media dilation divided into five groups each group includes 20 patients, mean age 30–45y. group 1 without regimen diet considered as a control group, group 2 on diet regimen, group 3 diet plus cumin, group 4 diet plus lemon, group 5 diet plus cumin and lemon.

Results: There was statistically significant difference in flow mediated dilation of the brachial artery between all groups and group 1 with better values in group 3 yogurt with lemon and cumin group, however there was no differences between other groups. There was statistically significant difference between all groups and group 1 in intima media thickness, LDL, cholesterol, triglycerids, BMI, glucose level, HA1C, serum creatinine with higher values in group 1, and between all groups and group 1 in HDL with lower values in group 1. There was statistically significant difference in those use lemon and cumin and all other groups in HDL with higher values in first group.

Conclusion: Combination of lemon and cumin raise the protective effect of either component alone in preventing premature atherosclerosis in obese patients.

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