ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P150 | DOI: 10.1530/endoabs.63.P150

Effects of diabetes mellitus and autoimmune thyroiditis on features of rheumatoid arthritis

Anton Dvorovkin, Vitaly Odin, Vadim Tyrenko & Michael Toporkov


Military Medical Academy named after S.M. Kirov, Saint Petersburg, Russian Federation.


Background: It is known that rheumatoid arthritis (RA) can be a part of autoimmune polyglandular syndrome and be combined with endocrine diseases.

Objectives: To study the effects of autoimmune thyroiditis (AIT) and diabetes mellitus (DM) on the clinical and laboratory manifestations of RA.

Methods: The study included two groups of patients. The first group of patients included 24 patients (20 women and 4 men, mean age - 68.37±1.75 years) with a combination of RA and DM. The second group included 24 patients (20 women and 4 men, mean age - 59.1±2.13 years) with a combination of RA and AIT. In the group of patients with a combination of RA and DM 2 patients were with type 1 diabetes, 22 with type 2 diabetes. In a group of patients with RA and AIT 15 patients had euthyroidism, 8 had hypothyroidism, and 1 had hyperthyroidism. Patient groups were compared by statistical treatment and correlation analysis method for the following indices of rheumatoid arthritis: detection of rheumatoid factor in blood serum, presence of erosion on radiographs of the hands/feet, radiographic stage and on a scale of activity DAS-28.

Results: In both groups of patients similar data were obtained on the average results for the studied parameters (detection in the serum of the rheumatoid factor was noted in 75% and 87.5% of patients, erosion in 87.5% and 83% of patients, in 50% and 54% identified III X-ray stage of rheumatoid arthritis, a high degree of activity of rheumatoid arthritis was detected in 67% and 50% patients). However, using the Spearman correlation analysis in the first group of patients (combination of RA and DM), a direct relationship between the presence of erosion and the degree of activity of rheumatoid arthritis (DAS-28, R=0.39, P<0.05), as well as between the detection of rheumatoid factor in the blood and the degree of disease activity (R=−0.63, P<0.05). In the second group of patients (a combination of RA and AIT), a direct relationship was found between the detection of rheumatoid factor and the degree of disease activity (R=0.39, P<0.05).

Conclusions: Thus, in the first group of patients there is a stronger correlation between the clinical and laboratory indicators of RA, including the severity of bone destruction, than in patients with a combination of RA and AIT. This fact can speak about synergistic enhancement of damage to the joint tissue pathogenetic mechanisms inherent in both diabetes and RA.

Article tools

My recent searches

No recent searches.