Objective: Vitamin D deficiency has been related to extraskeletal manifestations such as insulin resistance, type 2 diabetes mellitus (DM) and obesity. The objective of this study was to assess the prevalence of vitamin D insufficiency and deficiency in a population of patients with prediabetes and with type 2 DM already established, and to see if there were differences according to different parameters.
Material and methods: Cross-sectional study, in which a total of 460 patients were selected, 230 of them with prediabetes and another 230 patients with type 2 DM, controlled in Endocrinology consultations. 50% of each group were women. The main variables determined were: weight, body mass index (BMI), abdominal perimeter, fasting glucose levels, and 25-OH vitamin D levels. Serum 25-OH vitamin D levels considered as sufficiency were>30 ng/ml; insufficiency was considered between 2030 ng/ml, and deficiency <20 ng/ml.
Results: The prevalence of vitamin D deficiency was 85.7%, being higher in women (92.8%) than in men (79.3%) (P <0.05). In patients with type 2 DM, the prevalence of vitamin D insufficiency was 7.1% and the prevalence of deficiency was 84.2%; while in patients with pre-DM, 5.7% had vitamin D insufficiency and 64.3% had deficiency of this vitamin (P <0.05). A greater deficiency was also observed in patients older than 65 years (88.3% vs. 76.1%, P <0.05); in patients with a higher BMI (91.2% of patients with BMI>30 kg/m2 had deficiency compared to 78.1% of those with BMI<30 kg/m2), and a greater abdominal perimeter (90.1% if abdominal circumference was >110 cm, compared to 81.3% in those with abdomen perimeter <110 cm).
|Prediabetes||Type 2 Diabetes Mellitus||P|
|Age (years)||59.1 (+4.1)||60.3 (+5.5)||>0.05|
|BMI (kg/m2)||31.4 (+4.9)||33.5 (+4.3)||>0.05|
|Abdominal perimeter (cm)||103.8 (+12.4)||123.1 (+11.1)||0.01|
|25-OH vitamin D levels (ng/dl)||19.3 (+4.2)||14.1 (+3.6)||0.02|
|Fasting glucose levels (mg)||115 (+12.6)||132 (+13.8)||0.01|
|Glycated hemoglobin (%)||5.8 (+0.6)||6.9 (+0.9)||0.01|
Conclusions: There is a high prevalence of vitamin D deficiency in population with type 2 diabetes mellitus, being higher in women, in patients with higher BMI and greater abdominal perimeter, and in those with established type 2 DM compared to patients with prediabetes.
18 - 21 May 2019
European Society of Endocrinology