Objective: The aim of this study is to evaluate the bone mineral density, hip geometry parameters and bone quality, measured by trabecular bone score (TBS) in patients with type 1 diabetes mellitus (T1DM).
Materials and methods: We examined 97 patients with T1DM (28 males, 69 females, age: 31 (24.9−37.7) yrs., duration of DM: 11 (7−19.5) yrs., HbA1c: 8.6 (7.1−10) %, BMI: 23.1 (21.9−25.7) kg/m2). The control group consisted of 77 health age- and BMI-matched persons (20 males, 57 females). Bone mineral density (BMD) and the TBS were measured with dual X-ray absorptiometry. Geometric parameters were determined using Advanced Hip Analysis program including hip axis length (HAL), cross-sectional moment of inertia (CSMI) and cross-sectional area CSA.
Results: T1DM patients had lower BMD both at spine (T1DM:−0.4(−1.60.4) vs. controls: 0.3(−0.70.8), P=0.001, respectively) and at femoral neck (T1DM: −0.6(−1.50) vs. controls: 0.1(−0.50.7), P<0.001, respectively), higher frequency of fragility Fx (T1D: n=21 vs controls: n=6, P=0.012, respectively), lower level of osteocalcin (T1D: 15.14(11.824.2) vs controls: 24.5(22.228.2) pg/ml, P<0.001, respectively) compared with controls. T1D patients had shorter hip axis length (HAL) than in control group (T1D: HAL 107(102113) vs. controls: 109(106116) mm, P=0.010, respectively). T1D patients had lower CSA (T1D: 145(127166) vs. controls: 160(139178) mm2, P=0.002, respectively) and TBS L1L4 (T1D: 1.382(1.2771.414) vs. controls: 1.428(1.3681.470) P=0.016, respectively) compared with controls.
Conclusions: BMD, TBS and CSA in patients with type 1 DM were lower in comparison to the control group. Structural changes of bone tissue may indicate the poor bone quality and might potentially predispose to higher fracture risk in T1DM patients.
18 - 21 May 2019
European Society of Endocrinology