ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P237 | DOI: 10.1530/endoabs.63.P237

Some risk factors of re-growth of non-functional pituitary adenomas in patients with growth hormone deficiency

Yulduz Urmanova1,2, Ashley Grossman3,4, Zamira Khalimova1,2, Michael Powell5, Marta Korbonits4, Mukhlisa Shakirova6, Vladimir Pankiv7, Dinara Alieva2 & Ortikali Tursunkulov1

1Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan; 2Republican Specialized Scientific Practical Medical Center of Endocrinology of Republic of Uzbekistan named by Ya.Kh.Turakulov, Tashkent, Uzbekistan; 3University of Oxford Research Fellow, Green Templeton College, London, UK; 4Saint Bartholomew’s Hospital, London, UK; 5National Center of Neurosurgery and Neurology, London, UK; 6Liv Hospital, Istanbul, Turkey; 7Ukraine State Medical Institute, Kiev, Ukraine.

Aim: The aim of investigation to determine clinical aggressiveness diagnostic markers in patients with non-functional pituitary adenomas (NFPA), and growth hormone deficiency (GHD) in the formation of gravity neuroendocrine disease symptoms.

Material and methods: We observed in 87 patients (including man – 44 women – 43) of which have a verified diagnosis of NFPA after surgery – 31 which were subjected transnasal adenomectomy of the pituiatary (TAG). Further analysis was performed on these patients, who were followed from 1 to 3 years.

Results: After the analysis of the frequency of remission and relapse NFPA data selectively in patients we studied the correlation between various parameters and the frequency of relapses. NFPA developed the scale of aggressiveness allowed to identify the risk factors of markers on the 3rd degrees, allowing to create a set of measures of tumor growth relapse prevention.

Conclusions: Comparative analysis of the results of our research showed that there was a direct correlation with these markers of aggressiveness flow NFPA as the young age of the patient, the first symptoms of a manifest disease, large tumor size, asymmetry, and the pituitary gland deformation, signs of tumor invasion into surrounding tissue/artery/cavernous sinus, the presence of small-cell and/or dark cell chromophobe adenomas panhypopituitarism.