ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P246 | DOI: 10.1530/endoabs.63.P246

Salivary carcinoma of the pituitary gland: an exceptional localization never described

Lahoussaine Abainou, Hamza Eljadi, Sanae Elhadri & Hicham Baizri


Department of Endocrinology, Diabetology and Metabolic Diseases, Military Hospital Avicenna, Marrakesh, Morocco.


Introduction: Epithelial-myoepithelial carcinoma is a rare, we report the case of a patient admitted for pituitary macroadenoma whose anatomopathological study was in favor of an epithelial-myoepithelial carcinoma at the level of the pituitary gland knowing that this is the first case described in Literature.

Clinical case: A 50-year-old man, admitted in July 2018 for pituitary macroadenoma with severe headache and blurry vision associated with polydipsia syndrome and asthenia. Magnetic resonance imaging showed a pituitary macroadenoma with compression of the optic chiasm. A tumor biopsy was performed whose pathological study showed a morphological and immunohistochemical profile of a secondary localization of epithelial-myoepithelial carcinoma probably developed on embryonic salivary parenchymal rests or secondary to primitive salivary tumor. The clinical examination as well as the MRI of the salivary glands is normal and thus we retain the diagnosis of salivary gland carcinoma developed on embryonic rests. The occurrence of these salivary gland rests in the pituitary gland is explained by direct transfer of intact seromucinous glands from the oral cavity, derivation from Rathke pouch remnants, or induction of pituitary epithelium by salivary gland mesenchyme. After discussing the case at the Multidisciplinary Care Teams, we decided to treat the patient by radiosurgery. Our observation is an exceptional case that is never described in the literature.

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