Introduction: Growth hormone deficiency (GHD) is a non-exceptional cause of short stature. Hormonal evaluation and hypothalamic-pituitary MRI are essential to establish the etiological diagnosis. The objective of our study is to assess the different pituitary lesions found in imaging in a group of children with GHD.
Patients and methods: This is a retrospective longitudinal study of 22 cases of GHD who underwent pituitary MRI examination collected in the Endocrinology-Diabetology Department of Mohammed VI University Hospital.
Results: The mean age at diagnosis was 10.9 years with a sex ratio (M/F) of 2.14. Mean height Z-score at time of diagnosis was −4.46 SD. The mean bone age (BA) at the time of diagnosis was 6.23 years. The delay of BA over the chronological age was of 5.37 years on average. The diagnosis of total GHD was found in 77.3% of patients and partial GHD in 22.7% of patients. The isolated deficiency was noted in 31.8% of cases and multiple deficiencies in 68.2% of cases. Magnetic resonance imaging of the hypothalamic-pituitary region was normal in 27.3% of cases. Pituitary stalk interruption was observed in 56.2% of patients, pituitary hypoplasia was observed in 18.8% of patients, an empty sella was observed in 12.5% of patients, and agenesis of anterior pituitary in 12.5% of patients.
Conclusion: The multiplanar capability of MR imaging plays an important role in the assessment of the hypothalamic-pituitary area and in determining the underlying cause of various pituitary disorders in GHD.
18 - 21 May 2019
European Society of Endocrinology