ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P335 | DOI: 10.1530/endoabs.63.P335

Lipid parameters during pregnancy

Violeta Mladenovic1,2, Marija Andjelkovic3,4, Zoran Gluvic5,6, Milena Mitrovic7,8 & Djuro Macut6,9


1Center for Endocrinology, Diabetes and Metabolic Diseases, Clinical Center «Kragujevac», Kragujevac, Serbia; 2Department of Internal Medicine, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 3Department of Laboratory Diagnostics, Clinical Center «Kragujevac», Kragujevac, Serbia; 4Department of Biochemistry, Faculty of Medical Sciences, University of Kragujevac, Kragujevac, Serbia; 5Division of Internal Medicine, Department of Endocrinology, Zemun Clinical Hospital, Belgrade, Serbia; 6School of Medicine, University of Belgrade, Belgrade, Serbia; 7Clinic for Endocrinology, Clinical Center Vojvodina, Novi Sad, Serbia; 8Faculty of Medicine, University of Novi Sad, Novi Sad, Serbia; 9Clinic for Endocrinology, Clinical Center Belgrade, Belgrade, Serbia.


Introduction: The basic characteristics of metabolism in pregnancy are changes from anabolic to catabolic conditions with an increase in insulin resistance, moderate, reversible increase in lipid concentration in the blood, and accumulation of fat stores in the mother’s tissues. Lipid metabolism is essential for the development of healthy pregnancy, and fatty acids are a significant source of energy and a key element for membrane synthesis, while cholesterol, in addition to the construction of membranes, is necessary for the synthesis of steroid hormones. The lipid profile changes atherogenically during normal pregnancy. These changes do not reflect the pathological condition, but they represent the necessary adjustment of the mother’s physiology in order to satisfy the energy needs of the fetus and prepare the organism of the mother for delivery and lactation. The lipid profile that mimics the pathological finding of Metabolic Syndrome is a common finding during the second half of pregnancy. The mechanisms of lipid metabolism change are not entirely clear.

Aim: The aim of this study is to analyse concentration of lipid parameters during pregnancy.

Matherial and methods: This study included 77 healthy pregnant women in the first trimester of pregnancy registered in Center for endocrinology CC Kragujevac. Blood samples were collected for tHol, HDL, LDL and TAG during 1., 2. 3rd trimester, as well 2 months after delivery.

Results: The mean age of patients was 30.8±4.7 years. The prevalence of thyroid disorder was in 9%, hypertension 5.2%, gestational diabetes 23.4% and smoking in 23.4% patients. It has been shown that as pregnancy progresses, the value of lipid parameters increases, especially total cholesterol and triglycerides. The highest increase was seen in the 3rd trimester of pregnancy. The difference in parameters of liporegulation during pregnancy occurs in the 2nd and 3rd trimesters, while it does not appear in the 1st trimester.

Table 1 Mean values of lipid parameters during pregnancy.
X ±SD (95%CI)1.trimester2. trimester3. trimesterAfter delivery
tHol (mmol/L)4.69±0.96 (4.42–4.86)6.52±1.35 (6.22–6.83)7.37±1.54 (7.02–7.72)5.76±1.28 (5.46–6.05)
HDL- cholesterol (mmol/L)1.49±0.39 (1.4–1.58)1.92±0.41 (1.83–2.01)1.83±0.45 (1.73–1.93)1.51±0.39 (1.42–1.59)
LDL- cholesterol (mmol/L)2.67±0.85 (2.48–2.86)3.87±1.17 (3.61–4.14)4.44±1.34 (4.13–4.74)3.84±1.26 (3.55–4.13)
triglycerides (mmol/L)1.12±0.63 (0.97–1.26)1.88±0.78 (1.71–2.06)2.68±1.13 (2.42–2.93)1.37±0.84 (1.18–1.65)

Conclusion: This study demonstrates that as pregnancy progresses, the value of lipid parameters increases, especially total cholesterol and triglycerides.

Keywords: Lipid parameters, pregnancy

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