Introduction: The basic characteristics of metabolism in pregnancy are changes from anabolic to catabolic conditions with an increase in insulin resistance, moderate, reversible increase in lipid concentration in the blood, and accumulation of fat stores in the mothers tissues. Lipid metabolism is essential for the development of healthy pregnancy, and fatty acids are a significant source of energy and a key element for membrane synthesis, while cholesterol, in addition to the construction of membranes, is necessary for the synthesis of steroid hormones. The lipid profile changes atherogenically during normal pregnancy. These changes do not reflect the pathological condition, but they represent the necessary adjustment of the mothers physiology in order to satisfy the energy needs of the fetus and prepare the organism of the mother for delivery and lactation. The lipid profile that mimics the pathological finding of Metabolic Syndrome is a common finding during the second half of pregnancy. The mechanisms of lipid metabolism change are not entirely clear.
Aim: The aim of this study is to analyse concentration of lipid parameters during pregnancy.
Matherial and methods: This study included 77 healthy pregnant women in the first trimester of pregnancy registered in Center for endocrinology CC Kragujevac. Blood samples were collected for tHol, HDL, LDL and TAG during 1., 2. 3rd trimester, as well 2 months after delivery.
Results: The mean age of patients was 30.8±4.7 years. The prevalence of thyroid disorder was in 9%, hypertension 5.2%, gestational diabetes 23.4% and smoking in 23.4% patients. It has been shown that as pregnancy progresses, the value of lipid parameters increases, especially total cholesterol and triglycerides. The highest increase was seen in the 3rd trimester of pregnancy. The difference in parameters of liporegulation during pregnancy occurs in the 2nd and 3rd trimesters, while it does not appear in the 1st trimester.
|X ±SD (95%CI)||1.trimester||2. trimester||3. trimester||After delivery|
|tHol (mmol/L)||4.69±0.96 (4.424.86)||6.52±1.35 (6.226.83)||7.37±1.54 (7.027.72)||5.76±1.28 (5.466.05)|
|HDL- cholesterol (mmol/L)||1.49±0.39 (1.41.58)||1.92±0.41 (1.832.01)||1.83±0.45 (1.731.93)||1.51±0.39 (1.421.59)|
|LDL- cholesterol (mmol/L)||2.67±0.85 (2.482.86)||3.87±1.17 (3.614.14)||4.44±1.34 (4.134.74)||3.84±1.26 (3.554.13)|
|triglycerides (mmol/L)||1.12±0.63 (0.971.26)||1.88±0.78 (1.712.06)||2.68±1.13 (2.422.93)||1.37±0.84 (1.181.65)|
Conclusion: This study demonstrates that as pregnancy progresses, the value of lipid parameters increases, especially total cholesterol and triglycerides.
Keywords: Lipid parameters, pregnancy
18 - 21 May 2019
European Society of Endocrinology