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Endocrine Abstracts (2019) 63 P369 | DOI: 10.1530/endoabs.63.P369


University Basurto Hospital, Bilbao, Spain.


Introduction: Maternal clinical thyroid disorders can cause reproductive complications. However, the effects of mild thyroid dysfunction are controversial. The impact of SH and thyroid autoimmunity on miscarriages, obstetric and perinatal outcomes are not yet well established and the effect of levothyroxine replacement in pregnant women with SH is unclear. The aim of this study was to evaluate the impact of thyroid autoimmunity in early pregnancy on obstetric and perinatal outcomes in pregnant women with SH.

Subjects and Methods: A retrospective cohort study in 108 women diagnosed of HS in the first trimester of pregnancy (TSH 4, 20–10 μU/mL, normal FT4). Based on the presence of thyroid autoimmunity defined as thyroid peroxidase antibodies (AbTPO) >34 IU/ml, we analysed clinical features and obstetric and perinatal outcomes. All women received levothyroxine replacement since week 11 of pregnancy until delivery.

Results: Mean age was 32±6.6 years. 13.9% of women had positive AbTPO. Women with thyroid autoimmunity had TSH values greater than women with negative AbTPO (9.8 vs 5.45 μU/mL; P=0.028). We did not find any differences in miscarriages, gestational diabetes, preterm delivery, Apgar test, children weight or development of postpartum thyroiditis between both groups.

Conclusions: In our population of pregnant women with SH, we did not find any impact of thyroid autoimmunity on obstetric and perinatal outcomes. It is unknown the effect of levothyroxine replacement on these parameters.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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