ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P567 | DOI: 10.1530/endoabs.63.P567

Cardiovascular risk in obese women with polycystic ovary syndrome using Framingham scoring system

Dusan Ilic, Ivana Bozic Antic, Bojana Popovic, Tamara Bogavac, Tatjana Isailovic, Valentina Elezovic Kovacevic, Sanja Ognjanovic & Djuro Macut

Clinic for Endocrinology Diabetes and Metabolic Diseases, Clinical Center of Serbia, Belgrade, Serbia.

Objectives: Women with polycystic ovary syndrome (PCOS) are at increased risk for cardiovascular disease. Aim of our study was to determine the frequency of cardiovascular risk factors using Framingham Scoring system (FSS) in PCOS and controls.

Methods: FFS included age, value of cholesterol and HDL (mmol/L), smoking and systolic blood pressure (sysBP, mmHg). We also determined LDL (mmol/l), oxidized LDL (OxLDL, U/l) and triglycerides (mmol/l). We studied 22 obese women with PCOS (mean age: 27.55±5.89 yrs, mean BMI: 29.32±3.86 kg/m2) diagnosed using Rotterdam 2003 Consensus criteria and respective obese controls.

Results: Between PCOS and controls we obtained: total cholesterol 5.62±1.55 vs. 4.75±0.62, P>0.05; HDL 1.21±0.24 vs. 1.41±0.36, P>0.05; LDL 91.20±36.71 vs. 56.31±22.98, P>0.05; OxLDL 91.2±36.71 vs. 56.31±22.98, P<0.05; triglycerides 1.87±1.01 vs. 1.193±0.83, P>0.05; sysBP 132.73±15.33 vs. 119.62±15.09, P<0.05. Age distribution for PCOS and controls was as following: 20 to 34 yrs in 86.4% and 92.3%, respectively; 35 to 39 yrs in 9.1 and 7.7%, respectively; 40 to 44 yrs in 4.5 and 0%, respectively. There were 45.5% smokers in PCOS and 61.5% in controls. Framingham Scoring showed 10 year risk of 2 to 10% in 13.6% of PCOS and 3.8% of controls, and 10 to 20% risk in 9.1% of PCOS and 3.8% of controls.

Conclusions: Significantly higher values of OxLDL were found in PCOS group. In spite of similar values of assessed lipid parameters between obese PCOS and controls, we found a higher 10 year risk for cardiovasular event in obese women with PCOS.

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