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Endocrine Abstracts (2019) 63 P77 | DOI: 10.1530/endoabs.63.P77

ECE2019 Poster Presentations Calcium and Bone 1 (60 abstracts)

The effect of parathyroidectomy on the BMD in postmenopausal women with mild primary hyperparathyroidism: the results of comparative retrospective dynamic study

Elena Brutskaya-Stempkovskaya 1 , Alla Shepelkevich 1 , Tatiana Leonova 2 , Natalia Rekechinskaya 2 , Artur Pisarenko 2 & Natalia Vasilieva 3


1Belorussian State Medical University, Minsk, Belarus; 2Minsk City Clinical Oncologic Dispensary, Minsk, Belarus; 3Republic Center of Medical Rehabilitation, Minsk, Belarus.


Objective: To study the effect of parathyroidectomy (PTE) on the BMD in postmenopausal women with primary hyperparathyroidism (PHPT).

Materials and methods: We studied 38 postmenopausal women with mild PHPT without osteoporosis (T-score ≥ −2,5 by DXA). In 20 patients was performed PTE, the comparison group:18 postmenopausal patients with PHPT. The duration of observation was 1 year. Examination: total calcium, Ca++, phosphorus, PTH, DXA.

Results: The average age was 63.1±8.74 years, the duration of menopause was 13.4±3.52 years. The were no differences in the age (U=126.5, P=0.120), height, m (U=504.5, P=0.478), weight, kg (U=3556.0, P=0.318), BMI, kg/m2 (U=3578.5, P=0.350), duration of menopause, years (U=146.5, P=0.022), calcium total, mmol/l (U=0, P=1.000), PTH (U=11.5, P=0.655), BMD L1-L4total (U=158, P=0.530), BMD Hiptotal (U=157.0, P=0.520) in the both group. After surgical treatment, a significant decrease in calcium and PTH was detected. Against the background of the normalization of indicators of calcium-phosphorus metabolism, a significant increase in BMD L1-L4total (T=38.5, P=0.041) and BMD Hiptotal (T=51.5, P=0.046) was observed. In the group of patients without PTE, there was a significant decrease in BMD L1-L4total (T=20.0, P=0.013), BMD Hiptotal (T=22.0, P=0.017) against the background of continuing hypercalcemia (T=59.5, P=0.420) and elevated PTH (T=64.0, P=0.836) content in the blood serum.

Conclusion: The results of a retrospective study confirm the high efficacy of PTE in the postmenopausal women with mild PHPT to prevent bone loss.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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