ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P77 | DOI: 10.1530/endoabs.63.P77

The effect of parathyroidectomy on the BMD in postmenopausal women with mild primary hyperparathyroidism: the results of comparative retrospective dynamic study

Elena Brutskaya-Stempkovskaya1, Alla Shepelkevich1, Tatiana Leonova2, Natalia Rekechinskaya2, Artur Pisarenko2 & Natalia Vasilieva3

1Belorussian State Medical University, Minsk, Belarus; 2Minsk City Clinical Oncologic Dispensary, Minsk, Belarus; 3Republic Center of Medical Rehabilitation, Minsk, Belarus.

Objective: To study the effect of parathyroidectomy (PTE) on the BMD in postmenopausal women with primary hyperparathyroidism (PHPT).

Materials and methods: We studied 38 postmenopausal women with mild PHPT without osteoporosis (T-score ≥ −2,5 by DXA). In 20 patients was performed PTE, the comparison group:18 postmenopausal patients with PHPT. The duration of observation was 1 year. Examination: total calcium, Ca++, phosphorus, PTH, DXA.

Results: The average age was 63.1±8.74 years, the duration of menopause was 13.4±3.52 years. The were no differences in the age (U=126.5, P=0.120), height, m (U=504.5, P=0.478), weight, kg (U=3556.0, P=0.318), BMI, kg/m2 (U=3578.5, P=0.350), duration of menopause, years (U=146.5, P=0.022), calcium total, mmol/l (U=0, P=1.000), PTH (U=11.5, P=0.655), BMD L1-L4total (U=158, P=0.530), BMD Hiptotal (U=157.0, P=0.520) in the both group. After surgical treatment, a significant decrease in calcium and PTH was detected. Against the background of the normalization of indicators of calcium-phosphorus metabolism, a significant increase in BMD L1-L4total (T=38.5, P=0.041) and BMD Hiptotal (T=51.5, P=0.046) was observed. In the group of patients without PTE, there was a significant decrease in BMD L1-L4total (T=20.0, P=0.013), BMD Hiptotal (T=22.0, P=0.017) against the background of continuing hypercalcemia (T=59.5, P=0.420) and elevated PTH (T=64.0, P=0.836) content in the blood serum.

Conclusion: The results of a retrospective study confirm the high efficacy of PTE in the postmenopausal women with mild PHPT to prevent bone loss.

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