ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P882 | DOI: 10.1530/endoabs.63.P882

Vitamin D receptor gene polymorphisms and lipid profile in different vitamin D status women

Alena Andreeva1, Daria Burmistrova1, Anna Bystrova1,2, Alexandra Kozyreva1, Olga Belyaeva1,2 & Tatiana Karonova1,2

1Almazov National Medical Research Centre, St Petersburg, Russian Federation; 2Pavlov First State Medical University, St Petersburg, Russian Federation.

Objective(s): Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms can be associated with atherogenic lipid profile. The results of recent studies in different populations are contradictory. The aim of study was to assess serum lipids in women with different vitamin D status carrying various VDR gene variants.

Materials and methods: We examined 697 women aged 35 to 55 y.o. (mean 43.4±0.3). Anthropometric parameters (height (m), weight (kg), BMI, waist circumference (cm)) were measured. 25(OH)D serum level assessment was done by immunoassay (AbbottArchitect8000, USA), serum lipid profile – standard method. VDR gene variants rs1544410 (BsmI), rs7975232 (ApaI), rs731236 (TaqI), and rs2228570 (FokI) were evaluated by polymerase chain reaction-restriction fragment length polymorphism method.

Results: Result showed high prevalence of abdominal obesity (75.5%), dyslipidemia (69.6%), vitamin D insufficiency/deficiency (90.6%) in the study population. Women with vitamin D deficiency had increased risk of HDL cholesterol reduction (OR2.60[1.04-6.49]Cl95%). Serum 25(OH)D level did not differ between rs1544410 (BsmI), rs7975232 (ApaI), rs731236 (TaqI), and rs2228570 (FokI) VDR genotypes. BB genotype carriers of rs1544410 (BsmI) demonstrated higher triglyceride levels than subjects with Bb and bb genotypes (1.54±0.09 vs 1.32±0.04). A allele carriers of rs7975232 (ApaI) had higher total cholesterol (5.52±0.07 mmol/l vs 5.14±0.15 mmol/l) and LDL cholesterol levels (3.54±0.06 mmol/l vs 3.25±0.12 mmol/l) compared to women with aa genotype.

Conclusion(s): The study revealed decreased HDL level in women with vitamin D deficiency and the association between rs1544410 (BsmI) and rs7975232 (ApaI) VDR genotypes and atherogenic dyslipidemia.

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