Endocrine Abstracts

Introduction: Latent autoimmune diabetes in adults (LADA) is autoimmune diabetes occurring in a subject over 30 years of age with positive anti-island antibodies and insulin therapy after 6 months. Inaugural ketosis is an unusual presentation at the time of diagnosis due to the slow progression of beta cell destruction. The purpose of this work is to point out the different revelation modalities of LADA patients

Patients and methods: A cross-sectional descriptive study was conducted in 27 LADA patients hospitalized in the endocrinology department of the Mohammed VI University Hospital of Marrakech.

Results: The mean age of patients was 47.6 years and the mean age of discovery was 39.7 years with extremes of 30 to 56 years. The sex ratio was 1.4 with a female predominance. The circumstances of discovery were hyperglycemia in 2/3 of the cases and an inaugural ketosis in 1/3 of the cases. 50% of our patients have normal BMI, 15.3% are thin, 15.3% are overweight and 19.2% are obese. Waist circumference was pathological in 57% of patients and 19.2% had hypertension.

Conclusion: Our study showed that Diabetic ketoacidosis, although rare, may be the first manifestation of latent autoimmune diabetes in adults, and should be insulin-treated