ISSN 1470-3947 (print) | ISSN 1479-6848 (online)

Endocrine Abstracts (2019) 63 P991 | DOI: 10.1530/endoabs.63.P991

Neuroimaging in the diagnosis of neuroplasticity in patients with diabetes mellitus

Mariia Matveeva1, Natalie Zhukova1, Ivan Tolmachov1, Elena Ermak2 & Sergey Babenko3


1Siberian State Medical University, Tomsk, Russian Federation; 2Medical Institute named S.Berezin, Tomsk, Russian Federation; 3Edical Institute named S.Berezin, Tomsk, Russian Federation.


The goal was to study neuroplasticity in patients with diabetes mellitus using neuroimaging techniques. We examined 80 patients with diabetes mellitus type 1 and 2. All were conducted general clinical examination, neuropsychological testing - MoCa test, test 12 words. All patients underwent continuous glycemic monitoring and HbA1c assessment. An MRI study was also performed on Siemens 1.5 T, the protocol included a standard examination of the brain, a proton spectroscopy, and functional MRI at rest and with paradigms. As a result, changes in the metabolites in the hippocampus were found in patients with diabetes mellitus type 1 and in the temporal and frontal areas in patients with type 2 diabetes mellitus. Resting fMRI revealed many artifacts, however, quiescent networks were identified. When conducting the exercise with a load, zones of activation were identified for various stimuli, often a decrease in demand for a task.

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