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Endocrine Abstracts (2019) 63 S23.1 | DOI: 10.1530/endoabs.63.S23.1

Spain.


Microbiota plays a major role in health and disease in humans. Sex hormones influence the diversity and composition of the gut microbiota. Polycystic ovary syndrome (PCOS) is the most prevalent endocrine disorder in women of reproductive age (6–20%). PCOS is characterized by the association of androgen excess with oligomenorrhea, anovulatory infertility, and increased metabolic risk factors. The study of the interaction between gut microbiota and sex hormones in PCOS could be key to developing future personalized microbiota-based therapies. The mechanism underlying the association of sexual steroids and gut microbiota composition remains unclear. Very little evidence has been published regarding the implication of microbiota in women with PCOS. However, some studies have found a lower diversity and differential microbiota composition between women with and without PCOS, as well as correlations with clinical parameters of PCOS. Studies of PCOS animal models confirm that hyperandrogenism is capable of modifying the diversity of the gut microbiota community, and this may be a potential mechanism in the pathogenesis of PCOS. The current limitation of our knowledge about molecular mechanisms linking specific bacteria and PCOS highlights the need of interventional studies. Modulation and manipulation of gut microbiome will boost the efficacy of treatments to prevent the deleterious effect of hyperandrogenism on these women and improving their care.

Volume 63

21st European Congress of Endocrinology

Lyon, France
18 May 2019 - 21 May 2019

European Society of Endocrinology 

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