Searchable abstracts of presentations at key conferences in endocrinology
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Society for Endocrinology BES 2019

Brighton, United Kingdom
11 Nov 2019 - 13 Nov 2019

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Come and exchange knowledge, share experiences and strengthen collaborations across our global community of endocrinologists!


Neuroendocrinology, Pituitary and Neoplasia

ea0065oc2.1 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019

Differential effects of subcutaneous pulsatile versus oral hydrocortisone replacement therapy on fMRI resting state and task based emotional processing in patients with primary adrenal insufficiency

Russell Georgina , Kalafatakis Konstantinos , Thakrar Jamie , Hudson Elizabeth , Alim Lina , Marchant Nicola , Thirard Russell , Brooks Jonathan , Thai Jade , Harmer Catherine , Lightman Stafford

Background : Patients with primary adrenal insufficiency (PAI) describe significant impairments in quality of life. Current replacement regimes are non-physiological. Animal studies indicate that pulsatile presentation of endogenous glucocorticoids is critical for normal transcriptional and behavioural responses. Healthy volunteer work also shows that pattern of glucocorticoid presentation alters cognitive and emotional processing.Objective: To assess th...

ea0065oc2.2 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019

Investigating the role of AIP in pituitary tumourigenesis

Mistry Anisha , Solomou Antonia , Vignola Maria Lillina , Lim Chung Thong , Herincs Maria , Caimari Francisca , Costa Alejandro Ibanez , Begalli Federica , Gualtieri Angelica , Roncaroli Federico , Rizzoti Karine , Gaston-Massuet Carles , Korbonits Marta

Introduction: Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene predispose to growth hormone (GH, 90% of patients) or prolactin (PRL)-secreting tumours, with negligible number of patients with other pituitary tumour types. Animal models of acromegaly are scarce and Aip models have controversial data. Therefore we have generated two pituitary-specific Aip knockout mouse models to study the consequences of loss of AIP p...

ea0065oc2.3 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019

ErbB receptor signalling in MCF7 breast cancer cells: an information theoretic approach

Pope Robert JP , Welsh Gavin I , Coward Richard J M , McArdle Craig A

Epidermal growth factor (EGF) and heregulin (HRG) act via ErbB receptors, to stimulate Akt and ERK. These drive breast cancer cell proliferation and the network is targeted in cancer therapy (1). Single cell responses show marked cell-cell variation and information theory provides statistical measures that take the effect this noise has on information transfer into account (2). Here we quantify the mutual information (MI) between stimulus concentration and effects in MCF7 cell...

ea0065oc2.4 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019

Investigating the role of vagal Y2R in PYY3-36-mediated appetite suppression

Alonso Aldara Martin , Cork Simon C , Ma Yue , Herzog Herbert , Bloom Stephen R , Distaso Walter , Murphy Kevin G , Salem Victoria

Introduction: The gut hormone peptide YY 3-36 (PYY3-36) is secreted postprandially from intestinal L-cells to signal satiety. Peripheral administration of PYY3-36 suppresses food intake in rodents and humans. PYY3-36-based drugs are therefore promising anti-obesity treatments. It has been proposed that circulating PYY3-36 supresses appetite via the Y2 receptor (Y2R) in the hypothalamic arcuate nucleus (ARC). The vagus nerve, the majo...

ea0065oc2.5 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019

Efnb2 controls pituitary gland development by regulating proliferation of the pituitary stem/progenitor cells and EMT within the pituitary stem cell niche

Gualtieri Angelica , Nicholson James , Tan Rachael , Jimenez Fernando , Dattani Mehul , Guasti Leonardo , Gaston-Massuet Carles

Efnb2 encodes for the ligand Ephrinb2 that binds to its cognate Eph receptor, with which plays an integral role in angiogenesis, stem cell regulation and tumorigenesis. Using a pituitary-specific Cre-driver (Hesx1Cre), we conditionally deleted Efnb2 from the early stem/progenitor cells (PSCs) of the developing pituitary gland. We found that Efnb2 is expressed in PSCs both during embryogenesis and adulthood, suggesting its...

ea0065oc2.6 | Neuroendocrinology, Pituitary and Neoplasia | SFEBES2019

Post-operative copeptin analysis as a predictor of diabetes insipidus after pituitary surgery

Rostom Hussam , Noronha Sean , Jafar-Mohammadi Bahram , Halliday Jane , Cudlip Simon , James Tim , Guha Nishan , Shine Brian , Pal Aparna

Background: Diabetes insipidus (DI) is a recognised complication of pituitary surgery, with current diagnosis requiring clinical observation aided by plasma and urine electrolytes and osmolalities. Copeptin, a 39 amino acid glycopeptide secreted in equimolar quantities to ADH, is a stable surrogate marker of ADH release and has potential to facilitate prompt diagnosis of post-operative DI. This assay has been shown to accurately predict which patients are likely to develop DI ...