Endocrine Abstracts (2019) 65 P208 | DOI: 10.1530/endoabs.65.P208

Assessment of cardiovascular disease risk in subjects with pre-diabetes

Milica Marjanovic Petkovic1, Miljanka Vuksanovic1, Ivana Sasic2 & Teodora Beljic Zivkovic1


1Belgrade School of Medicine and Zvezdara University Medical Center, Belgrade, Serbia; 2Cardiovascular Institute Dedinje, Belgrade, Serbia


Introduction: Prediabetes carries a risk of diabetes and cardiovascular disease (CVD). Assessment of CVD risk in prediabetes is not as routine, as is assessment of diabetes risk. However, it is not less important. This can be done through conventional SCORE charts and through coronary artery calcium (CAC) score. CAC is examined through multislice CT. Calcifications indicate late-stage subclinical coronary atherosclerosis. The AIM of our study was to assess traditional CVD risk through score charts and CAC in subjects with prediabetes (preDM) and to evaluate whether any correlation exists between the two.

Methods: After diagnosing preDM with oral glucose tolerance test and HbA1c, ECG was performed and subjects were evaluated for CVD risk through Score charts. Thereafter, all subjects were appointed for multislice CT to obtain the CAC.

Results: 80 subjects with preDM were screened for CVD. CAC score of 0 was present in 35 subjects. Minimal calcifications with a CAC score of 1–10 AU were present in 10 subjects with pre DM. Moderate calcification of 11–100 AU were present in 18 subjects. 12 subjects had significant calcifications with 101–400 AU. Five subjects had a CAC score >400 AU. Score risk below 2% was present in 20 subjects. Score risk of 3–4% was present in 10, 5–9% risk was present in 16 and a score risk of 10–14% was present in 8 subjects. Twenty six subjects with PreDM has a score risk of 15% and more. No significant correlation was found between Score charts and CAC. However, a trend of finding more calcifications in those with a 10% and above Score risk was noted.

Conclusion: An approach to risk assessment that combines the traditional Score charts with a more personalized atherosclerosis-imaging model may be appropriate for high risk subjects with pre diabetes.

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