Endocrine Abstracts (2019) 65 P212 | DOI: 10.1530/endoabs.65.P212

An audit of SGLT2-inhibitors in the management of type 2 diabetes in Sligo University Hospital Ireland: metabolic and haemodynamic outcomes

Avinash Radhakrishna & Catherine Mchugh


Sligo University Hospital, Sligo, Ireland


Introduction: Sodium-Glucose Co-Transporter-2 (SGLT2) inhibitors are the latest class of anti-hyperglycaemic agents which reduce blood glucose by increasing urinary glucose excretion.

Aims: 1) To assess the metabolic and haemodynamic changes associated with SGLT-2 inhibitors in patients attending Sligo University Hospital (SUH) Ireland.

2) To enhance prescriber awareness across disciplines regarding the metabolic and haemodynamic benefits in addition to improving cardio-renal outcomes as demonstrated in the EMPAREG, CANVAS & DECLARE meta-analysis

Methodology: After screening for eligibility, we selected 98 patients prescribed SGLT2-Inhibitors between January 2014 to December 2018. We excluded those with incomplete data and whose medications were stopped during the initial 6-month period. Retrospective data was collected from Medical Charts, NIMIS®, IPMS® and ProWellness IT Diabetes Database®. Data was collected at Baseline and at 6 months after the start of SGLT-2i for body weight, blood pressure, HbA1c and lipid profile.

Mean HbA1c was 8.89(1.44) % at baseline which dropped significantly to 8.04(1.22) % at 6 months. A similar highly significant change was observed when comparing weights at baseline and 6 months: 95.49(20.5) kg to 93.29(19.6)kg. Blood pressure changes were remarkable but there was only a modest improvement of HDL with no significant changes in Total Cholesterol, LDL and Triglycerides.

Results:

Baseline Characteristics (n=98)
Age (Years)62.13 ± (12.29)
DM Duration (Years)1–29
Median Treatment (Years)2
Sex (Male/Female)61/37
Changes in The Examined Variables After 6 Months Of Starting SGLT2-Inhibitors
Pre-Treatment6 MonthsP
HbA1c (%)8.808.04<0.0001
Systolic Blood Pressure (mmHg)143.75135.41<0.0001
Diastolic Blood Pressure (mmHg)80.6077.96<0.0001
Weight (kg)95.4993.29<0.0001
HDL-C (mmol/l)1.1541.0950.004

Conclusion: The use of SGLT-2 Inhibitors in SUH was associated with significant metabolic and haemodynamic improvements which were better than expected when compared with those documented in large volume trials

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