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47th Meeting of the British Society for Paediatric Endocrinology and Diabetes

Cardiff, UK
27 Nov 2019 - 29 Nov 2019

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BSPED 2019, 27 - 29 November 2019; Cardiff, UK


Oral Communications 5

ea0066oc5.1 | Oral Communications 5 | BSPED2019

Project to develop BSPED UK standardised guidelines for sex hormone priming and glucagon stimulation testing (GST) in children and adolescents

Wei Christina , Musson Pauline , Clayton Peter , Dattani Mehul , Randell Tabitha , Crowne Elizabeth C

Background: The GST is commonly used in children and adolescents for the diagnosis of growth hormone (GH) deficiency. Evidence supports the use of sex steroid priming to improve diagnostic accuracy in GH provocation tests. This project, undertaken on behalf of the BSPED Clinical Committee, aims to identify current practice and develop consensus in sex hormone priming and GST protocols for the development of standardised UK protocols.Method: (1) Audit of ...

ea0066oc5.2 | Oral Communications 5 | BSPED2019

Longitudinal outcomes of well, term infants who present with persistent hyperthyrotropinaemia

Ng Sze May , Oryan Tal , Katkat Nancy , Ayoede Kayode , Aleem Mahreen

Background: Neonatal hyperthyrotropinaemia (HT) is defined by elevated thyroid stimulating hormone (TSH) and normal free-thyroxine (FT4) level. Persistent HT in the neonatal period is often a diagnostic dilemma for clinicians to either treat to prevent subclinical hypothyroidism or to wait and monitor thyroid function tests (TFTs).Methods: As part of an audit, 1449 term infants who had TFTs undertaken as part of a prolonged jaundice screen from 2012&#150...

ea0066oc5.3 | Oral Communications 5 | BSPED2019

Causes of central diabetes insipidus in children: a single-centre experience

Arya Ved Bhushan , Korkmaz Huseyin Anil , Kalitsi Jennifer , Kapoor Ritika R , Buchanan Charles R

Background: Central diabetes insipidus (CDI) presents with various underlying diagnoses in children.Objective: To determine causes of CDI and long-term outcome in children and adolescents from a Tertiary Paediatric Endocrinology unit providing Regional Paediatric Neurosurgery and head trauma services.Methods: The clinic database was searched to identify patients with CDI managed between 1993 and 2019. Relevant clinical information ...

ea0066oc5.4 | Oral Communications 5 | BSPED2019

Tolvaptan for hyponatraemia in infants with brain tumours

Gopal-Kothandapani Jaya Sujatha , Bockenhauer Detlef , Spoudeas Helen

Background: Syndrome of Inappropriate Antidiuretic Hormone secretion (SIADH) is a well-recognized complication of intracranial tumours (ICT). Fluid restriction as treatment for SIADH is challenging in infants since it is coupled with calorie restriction. Moreover, it may conflict with chemotherapy-associated hyperhydration protocols. Existing evidence on the use of the type-2 vasopressin receptor antagonist (Tolvaptan) for refractory SIADH in infants and young children is limi...

ea0066oc5.5 | Oral Communications 5 | BSPED2019

Recombinant human Insulin-like growth factor-1 (rhIGF-1) therapy: a 15-year experience in a tertiary care centre

Aftab Sommayya , Prentice Philippa , Katugampola Harshini , Dattani Mehul

Background: Recombinant human Insulin-like growth factor-1 (rhIGF-1) is the only treatment for short stature due to primary IGF-1 deficiency and related disorders. However, treatment needs meticulous monitoring for adverse effects, especially hypoglycemia, obstructive sleep apnoea (OSA), raised intracranial hypertension, cardiac complications and skin reactions.Method: To determine therapeutic potential, efficacy and safety of rhIGF-1 treatment, case not...

ea0066oc5.6 | Oral Communications 5 | BSPED2019

Monitoring and long-term disease activity in children with X-linked hypophosphataemia on conventional therapy

Uday Suma , Shaw Nick , Mughal Zulf , Randell Tabitha , Hogler Wolfgang , Santos Rui , Padidela Raja

Background: Conventional treatment of X-linked hypophosphataemic rickets (XLH) involves administration of oral phosphate and vitamin D analogues. Newer therapies such as Anti Fibroblast Growth Factor 23 antibodies (burosumab) have now become available. An important treatment goal is to heal rickets; assessed by normalisation of serum alkaline phosphatase (ALP) levels and resolution of radiological signs of rickets.Objectives: (1) Assess disease severity ...

ea0066oc5.7 | Oral Communications 5 | BSPED2019

Longitudinal changes in external masculinisation scores in boys born with XY disorders of sex development

Kraria Loubna , Alimussina Malika , Ahmed S Faisal

Introduction: Although a number of studies have reported on the External Masculinisation Score (EMS) and have validated its use for numerical descriptions of the external genitalia, the methodology in these studies has not considered longitudinal changes in EMS.Objectives: To examine longitudinal changes in EMS in boys with XY Disorders of Sex Development (DSD) and determine the causes of these changes.Methods: All boys of confirme...

ea0066oc5.8 | Oral Communications 5 | BSPED2019

TSH-Receptor testing in pregnancy allows stratification of risk of neonatal thyrotoxicosis and promotes earlier discharge

Law James , Chauhan Hemma , Wynn-Davies Anneli

Background: Local guidelines for infants born to mothers with a history of thyrotoxicosis previously recommended that infants were observed in hospital until thyroid function tests were checked on day 4, with follow up on day 10, causing inconvenience to families and unnecessary cost to services. Following a literature search, our revised local guidelines recommend low-risk infants can be discharged on day 0 without follow up, stratified using maternal TSH-receptor antibody (T...

ea0066oc5.9 | Oral Communications 5 | BSPED2019

Rare causes of primary adrenal insufficiency (PAI) in children from Sudan

Qamar Younus , Maharaj Avinaash , Chan Li , AbdulBagi S , Abdullah M , Metherell Louise

Background: Primary adrenal insufficiency (PAI) is a rare, genetically heterogenous condition, characterised by hypocortisolaemia and high plasma ACTH levels in the presence or absence of mineralocorticoid deficiency. PAI can be life-threatening if unrecognised, misdiagnosed or under/untreated. Familial glucocorticoid deficiency (FGD) is a rare autosomal recessive form of PAI characterised by isolated glucocorticoid insufficiency. Mutations in the MC2R/ACTH receptor, ...

ea0066oc5.10 | Oral Communications 5 | BSPED2019

Review of neonatal cortisol evaluation between 2012–2018 in a single centre: trends, outcomes and associations

Makaya Taffy , Sarvasiddhi Satish , van Boxel Elizabeth , Menon Smrithi , Shine Brian

Background: Neonatal cortisol assessment is indicated in suspected adrenal insufficiency.Aims/objectives: Review of neonatal cortisol assessment within our Trust over seven years, to analyse trends, indications, outcomes; and relationships between gestational age (GA), birth weight (BW) and cortisol assessment.Methodology: From cortisol results on neonates (≤30 days age) between 2012–2018 (inclusive) we identified random...