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Endocrine Abstracts (2019) 67 O41 | DOI: 10.1530/endoabs.67.O41

EYES2019 7th ESE Young Endocrinologists and Scientists (EYES) Meeting Oral Presentations (67 abstracts)

Clinical features of primary hyperparathyroidism in women of different age groups according to the Russian Online Register database

SS Mirnaya , VL Volodicheva , EE Bibik & NG Mokrysheva

Endocrinology Research Centre, Moscow, Russian Federation.

Objective: The aim of the study was to compare the clinical features in three age-groups of women with primary hyperparathyroidism.

Methods: The data about biochemical profile and disease complications in women with active stage of disease (n=645) was collected from the Russian Primary Hyperparathyroidism Registry. Group 1 included women 20–49 years old (n=215) unless the patients with suspected or confirmed multiple endocrine neoplasia syndrome, group 2 - women 50–69 years old (n=215), group 3 - women over 70 years old (n=215). Data analysis was performed using Statistica v. 13.3 (TIBCO Software Inc., USA). Three groups were compared using the Kruskel-Wallis test.

Results: There was no statistically significant difference between the three groups with respect to parathyroid hormone, total and ionized serum calcium levels (P>0.05); however the daily urinary calcium excretion increased (P<0.001) and glomerular filtration rate decreased (P<0.001) with age. Using X-ray densitometry in group 1 osteoporosis occurred in 21.9%, in group 2 – 50.2%, in group 3 - 69.8% (P<0.001) and low-energy fractures were presented in 10.7%, 17.2% and 36.7% respectively (P<0.001). Kidneys ultrasound examination showed that younger patients had nephrolithiasis less often: group 1 – 2.79%, group 2 – 5.58% and group 3 – 9.30% (P=0.016). Also the frequency of hypertension was age-dependent (17.2%, 36.7% and 52.6% of cases respectively) (P<0.001).

Conclusion: According to our study the frequency of classical and non-classical primary hyperparathyroidism complications increases with age probably because of comorbid status that must be considered in management strategies.

Volume 67

7th ESE Young Endocrinologists and Scientists (EYES) Meeting

European Society of Endocrinology 

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