Endocrine Abstracts

Objective: The aim of the study was to compare the clinical features in three age-groups of women with primary hyperparathyroidism.

Methods: The data about biochemical profile and disease complications in women with active stage of disease (n=645) was collected from the Russian Primary Hyperparathyroidism Registry. Group 1 included women 20–49 years old (n=215) unless the patients with suspected or confirmed multiple endocrine neoplasia syndrome, group 2 - women 50–69 years old (n=215), group 3 - women over 70 years old (n=215). Data analysis was performed using Statistica v. 13.3 (TIBCO Software Inc., USA). Three groups were compared using the Kruskel-Wallis test.

Results: There was no statistically significant difference between the three groups with respect to parathyroid hormone, total and ionized serum calcium levels (P>0.05); however the daily urinary calcium excretion increased (P<0.001) and glomerular filtration rate decreased (P<0.001) with age. Using X-ray densitometry in group 1 osteoporosis occurred in 21.9%, in group 2 – 50.2%, in group 3 - 69.8% (P<0.001) and low-energy fractures were presented in 10.7%, 17.2% and 36.7% respectively (P<0.001). Kidneys ultrasound examination showed that younger patients had nephrolithiasis less often: group 1 – 2.79%, group 2 – 5.58% and group 3 – 9.30% (P=0.016). Also the frequency of hypertension was age-dependent (17.2%, 36.7% and 52.6% of cases respectively) (P<0.001).

Conclusion: According to our study the frequency of classical and non-classical primary hyperparathyroidism complications increases with age probably because of comorbid status that must be considered in management strategies.