Searchable abstracts of presentations at key conferences in endocrinology
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22nd European Congress of Endocrinology

05 Sep 2020 - 09 Sep 2020

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Europe's leading endocrinology congress showcasing the very best in the study and treatment of endocrine disorders.

Oral Communications

Endocrine-related Cancer

ea0070oc7.1 | Endocrine-related Cancer | ECE2020

Is Carney complex a breast cancer predisposing syndrome? prospective study of 50 women

Vaduva Patricia , Espiard Stéphanie , Jouinot Anne , Vantyghem Marie-Christine , Assié Guillaume , Catherine Cardot-Bauters , Raverot Gerald , Sylvie Hieronimus , Francoise Archambeaud , Hervé Lefebvre , Laure Nunes , Tabarin Antoine , Anne Lienhardt , Groussin Lionel , Guignat Laurence , Fideline Bonnet , North Marie-Odile , Bertherat Jerome

Introduction: Carney Complex (CNC) is a rare genetic syndrome, with multiple endocrine and non-endocrine neoplasia, mostly due to inactivating mutations of the PRKAR1A gene. CNC has a wide spectrum of manifestations : most frequently skin lesions, cardiac myxomas and primary pigmented nodular adrenocortical dysplasia (PPNAD), but also thyroid nodules, schwannomas, breast tumors (mainly myxoid fibroadenomas and ductal adenomas)… The present study was designed to ...

ea0070oc7.2 | Endocrine-related Cancer | ECE2020

The role of the tumour microenvironment in pituitary adenoma angiogenesis

Marques Pedro , Barry Sayka , Carlsen Eivind , Collier David , Ronaldson Amy , Awad Sherine , Mendoza Nigel , Muquit Samiul , Dorward Neil , Grieve Joan , Balkwill Frances , Grossman Ashley B , Korbonits Marta

Introduction: Angiogenesis is regulated by different components of the tumour microenvironment (TME) including cytokines and immune cells. Although angiogenesis has been studied in pituitary adenomas (PAs), the role of individual TME components in PA angiogenesis remains largely unknown. We aimed to characterise the role of the TME components in determining the angiogenesis of PAs, focusing on PA-infiltrating immune cells and the PA-derived cytokine network.<p class="abste...

ea0070oc7.3 | Endocrine-related Cancer | ECE2020

Sterol O-Acyl transferase 1 as a prognostic marker of adrenocortical carcinoma

Ferreira Lacombe Amanda M , Cauduro Soares Ibere , Bezerra-Neto João Evangelista , da Silva Charchar Helaine , Hoff Ana O , Almeida Madson Q , Weigand Isabel , Kroiss Matthias , Nogueira Zerbini Maria Claudia , Barisson Villares Fragoso Maria Candida

Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with an unfavorable prognosis. Despite the poor prognosis in the majority of patients, no improvements in treatment strategies have been achieved. Therefore, the discovery of new prognostic biomarkers is of enormous interest. Sterol-O-acyl transferase 1 (SOAT1) is involved in cholesterol esterification and lipid droplet formation. Recently, it was demonstrated that SOAT1 inhibition leads to impaired steroidogenesis ...

ea0070oc7.4 | Endocrine-related Cancer | ECE2020

Increased E2F1 mRNA and miR-17-5p expression may predict aggressiveness of pituitary neuroendocrine tumours

García-Martínez Araceli , Martínez-López Sebastián , López-Muñoz Beatriz , Cámara Rosa , Fajardo Carmen , Lamas Cristina , Silva-Ortega Sandra , Aranda Ignacio , Picó Antonio

Introduction: E2F1 regulates the expression of genes required for cell cycle progression and apoptosis. miR-17-5p regulates expression of E2F1. Both miR-17-5p and E2F1 have been described deregulated in cancer but they have been scarcely studied in human pituitary neuroendocrine tumours (PitNETs).The aim of the present study was to find biomarkers of aggressiveness in PitNETs and report the correlation between E2F1 and...

ea0070oc7.5 | Endocrine-related Cancer | ECE2020

Differential adrenal toxicity of SOAT1-inhibitors

Weigand Isabel , Sbiera Silviu , Kendl Sabine , Hanna Urlaub , Constanze Hantel , Katja Kiseljak-Vassiliades , Margaret E Wierman , Fassnacht Martin , Kroiss Matthias

Background: Mitotane is the only approved treatment for advanced adrenocortical carcinoma and was shown to inhibit Sterol-O-Acyl transferase 1 (SOAT1) which leads to the depletion of cholesterol esters and increase of free cholesterol in the ACC cell line H295R. Downstream activation of the endoplasmic reticulum stress (ER-stress) pathway results in decreased adrenocortical cell viability.Aim: To better characterize the effects of SOAT1 inhibition in ACC...

ea0070oc7.6 | Endocrine-related Cancer | ECE2020

Llaser ablation vs radiofrequency ablation for benign non-functioning thyroid nodules: six-month results of a randomised, parallel, open-label, trial (LARA trial)

Cesareo Roberto , Maurizio Pacella Claudio , Pasqualini Valerio , Campagna Giuseppe , Lauria Pantano Angelo , Pozzilli Paolo , Cianni Roberto , Manfrini Silvia , Crescenzi Anna , Palermo Andrea

Background: No direct prospective studies comparing laser ablation (LA) and radiofrequency ablation (RFA) for debulking benign non-functioning thyroid nodules (BNTNs) exist. We aimed to compare the efficacy and safety of both techniques in patients with solid or predominantly solid BNTN.Methods: This six-month, single-use, randomized open label parallel trial compared the following primary endpoints between the RFA and LA groups six months after treatmen...

ea0070oc7.7 | Endocrine-related Cancer | ECE2020

A rare case of lynch syndrome in a patient with metastatic malignant paraganglioma with SDHA mutation

Ares Blanco Jessica , Pujante Pedro , Rodriguez Raul , Lanes Soraya , Delgado Elías , Menéndez-Torre Edelmiro

Paragangliomas (PGLs) and pheochromocytomas (PCCs) are rare tumors that arise from the neuroendocrine tissue along the paravertebral axis with the ability to secrete cathecolamines. Up to 33% of these tumors may be hereditary either alone or as a component of a multiple tumor syndrome. Germline SDHA mutations are relatively frequent (7.6%) in patients with genetically unexplained PGL, even in the absence of familial or clinical indications for inherited PGL....