ECE2020 Audio ePoster Presentations Hot topics (including COVID-19) (110 abstracts)
Subclinical atherosclerosis is associated with anti-mullerian hormone levels in reproductively women
Eleni Armeni 1 , Stefanos Stergiotis 1 , Panagiota Chatzivasileiou 1 , Areti Augoulea 1 , Panagiotis Anagnostis 2 , Demetrios Rizos 3 , George Kaparos 3 , Andreas Alexandrou 1 , Georgios Georgiopoulos 4 , Christos Kontogiannis 4 , Kimon Stamatelopoulos 4 & Irene Lambrinoudaki 1
1National and Kapodistrian University of Athens, 2nd Department of Obstetrics and Gynaecology, Aretaieio Hospital, Athens, Greece; 2Aristotele University of Thessaloniki, Thessaloniki, Greece; 3National and Kapodistrian University of Athens, Hormonal and Biochemical Laboratory, Athens, Greece; 4National and Kapodistrian University of Athens, Department of Therapeutics, Vascular Laboratory, Alexandra Hospital, Athens, Greece
Introduction: The prevalence of cardiovascular disease in reproductively active women has received limited attention. Recent data indicated possible adverse effect of non-typical obstetrical risk factors with regards to cardiovascular function. We aimed to evaluate the potential association between anti-mullerian hormone (AMH), a known marker of ovarian reserve, with subclinical atherosclerosis in young premenopausal women.
Methods: This was a cross-sectional study, comprising of 70 premenopausal women, aged 32.7 ± 6.5 years. Fasting blood samples were obtained to assess serum AMH levels as well as the lipid profile. Vascular studies were performed in one session and included indices of vascular structure (e.g. carotid and femoral intima media thickness, IMT) as well as vascular function (e.g. flow-mediated dilation; carotid-femoral pulse wave velocity, PWV).
Results: Serum levels of total cholesterol associated negatively with AMH concentrations. Moreover, smokers had lower levels of AMH when compared with non-smokers. Mean AMH levels associated inversely with carotid and femoral IMT values, in all of the assessed segments. The association between AMH concentrations and combined carotid IMT or carotid bulb IMT remained significant, even after multivariable adjustment for various established cardiovascular risk factors. No correlation was identified between AMH levels and indices of functional vascular disease or other markers of cardiovascular disease.
Conclusion: AMH levels are negatively and independently associated with indices of subclinical atherosclerosis as well as serum levels of total cholesterol, in this sample of young, health, normally ovulating women.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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