Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2020) 70 AEP153 | DOI: 10.1530/endoabs.70.AEP153

ECE2020 Audio ePoster Presentations Bone and Calcium (121 abstracts)

Risk of fractures in primary hyperparathyroidism: A systematic review and metaanalysis

Henriette Svensson 1 , Lars Rolighed 2 , Torben Harsløf 1 & Lars Rejnmark 3


1Aarhus University Hospital, Internal Medicine and Endocrinology, AARHUS N, Denmark; 2Aarhus University Hospital, Otorhinolaryngology, Head and Neck Surgery, AARHUS N, Denmark; 3Aarhus University Hospital And Aarhus University, Internal Medicine and Endocrinology, AARHUS N, Denmark


Background and objective

An increased risk of fractures in Primary Hyperparathyroidism (PHPT) has been reported in a number of relatively small studies. Performing a systematic literature search we identified available studies and calculated common estimates by pooling results from the individual studies in a meta-analysis.

Methods: Searching EMBASE and PubMed using both free text word search and Mesh terms we identified published studies reporting the risk of fractures in PHPT compared to a control group or compared to the expected fracture rates from the general population. We calculated odds ratio (OR) with 95% confidence interval (CI).

Results: A total of 804 studies were identified of which 13 studies and a total number of 5457 PHPT patients and 13633 controls were included. Overall, risk of any fracture was increased compared to controls (OR 2.01; 95% CI, 1.61–2.50; I2 46%, 5 studies). Analysis of fracture risk at specific sites showed an increased risk of fracture at the forearm (OR 2.36; 95% CI, 1.64–3.38; I2 0%, 4 studies) and spine (OR 3.50; 95% CI, 1.66–7.89; I2 87%, 10 studies). Risk estimate for hip fractures was also increased although non-significantly (OR 1.27; 95% CI, 0.97–1.66; I2 0%, 3 studies). Risk of vertebral fractures (VFx) was also increased if analyses were restricted to only studies with a healthy control group (OR 5.76; 95% CI, 3.86–8.60; I2 29%, 6 studies), studies including only patients with mild PHPT (OR 4.22; 95% CI, 2.20–8.12; I2 57%, 4 studies), or studies including only postmenopausal women (OR 8.07; 95% CI, 4.79–13.59; I2 0%, 3 studies).

Conclusions: Overall, PHPT is associated with an increased risk of fractures. Although number of studies are limited – it seems that the risk is increased across different skeletal sites including patients with mild PHPT. Of notice, relative risk of VFx seems to be extraordinarily high in postmenopausal women.

Volume 70

22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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