ECE2020 Audio ePoster Presentations Diabetes, Obesity, Metabolism and Nutrition (285 abstracts)
Descriptive analysis of body composition and phase angle (PA) in achondroplastic patients: Case-control study
Isabel Mª Vegas-Aguilar 1 , Isabel Maria Cornejo Pareja 1 , Antonio Leiva Gea 2 , Francisco J Tinahones 1 & Jose Manuel García-Almeida 1
1Endocrinology and Nutrition Department, Virgen de la Victoria Universitary Hospital, Malaga, Spain; 2Traumatology Department, Virgen de la Victoria Universitary Hospital, Malaga, Spain
Introduction: Data on body composition in patients with achondroplasia are scarce. The Phase Angle (PA) is a bioelectric measurement of our body cells. The PA is considered to be a global prognostic factor that gives information about cellular function in relation to body composition.
Objectives: To describe body composition parameters PA, standardized PA (sPA), resistance (Rz), reactance (Xc), body cell mass (BCM), total body water (TBW), fat mass (FM), fat free mass (FFM) in a group of patients diagnosed with achondroplasia compared with controls paired by age and sex.
Material and Methods: Observational study of 33 subjects (24 patients with achondroplasia and 9 controls). Bioimpedanciometry (by using AKERN 101 equipment) as well as anthropometric, nutritional and analytical data were collected.
Results: Body composition parameters were significantly different between achondroplastic patients and the control group. PA values were significantly lower in achondroplastic patients than in controls (5.3 ± 0.1 deg vs 6.5 ± 0.7 deg, respectively; P = 0.001) as well as sPA (+0.9 ± 0.8 vs –1.1 ± 1.5 deg; P = 0.001). Other body composition measurements are detailed in table 1. In addition, the sPA significantly correlated with PA (r = 0.930), Xc (r = 0.873), BCM (r = 0.646) and height (r = 0.515).
| Achondroplastic Patients (n = 24) Mean (Standard deviation) | Controls (n = 9) Mean (standard deviation) | P | |
| Age (years) | 14.3 (1.6) | 14.0 (1.9) | 0.655 |
| Weight (Kg) | 36.1 (8.5) | 57.7 (12.4) | 0.000 |
| Height (cm) | 123.3 (9.3) | 164.7 (7.5) | 0.000 |
| FFM (Kg) | 30.5 (5.2) | 45.7 (7.1) | 0.000 |
| TBW (L) | 25.6 (3.6) | 32.7 (5.5) | 0.000 |
| BCM (Kg) | 15.0 (3.1) | 26.2 (4.7) | 0.000 |
| FM (Kg) | 5.6 (5.4) | 12.0 (7.8) | 0.012 |
| PA (deg) | 5.3 (1.0) | 6.5 (0.7) | 0.001 |
| sPA (deg) | –1.1 (1.5) | +0.9 (0.8) | 0.001 |
Conclusions: There are relevant differences in the crude and standardized phase angle between the achondroplastic and healthy populations, adjusted for age and sex. These differences are related to a lower cell mass (BCM, FFM) and less clearly with water (TBW) and fat depots (FM).
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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