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Endocrine Abstracts (2020) 70 AEP873 | DOI: 10.1530/endoabs.70.AEP873

ECE2020 Audio ePoster Presentations Thyroid (144 abstracts)

Treating thyroid nodules by radiofrequency: The delivered energy should be correlated with the volume reduction rate

Maurilio Deandrea 1 & Pierpaolo Trimboli 2


1Ospedale Mauriziano Umberto I, Endocrinology and Metabolism, Turin, Italy; 2Ente Ospedaliero Cantonale, Bellinzona e Lugano, Clinica di Medicina Nucleare e Imaging Molecolare, Centro di Competenza Diagnosi e Terapia delle Malattie Tiroidee, Lugano, Switzerland


Context: Radiofrequency ablation (RFA) was proven as effective in reducing thyroid nodules’ volume. However, whether technical procedure aspects could influence the volume reduction rate (VRR) has not been clarified.

Objective: To analyze the correlation of RFA power, duration and energy with VRR.

Design: Prospective study from June 2018 to December 2019.

Setting: Two primary-care centers using the same RFA procedure.

Patients or other participants: Adult outpatients undergoing a single-session RFA and 1-year post-treatment follow-up.

Intervention: RFA was performed by moving-shot technique with internally cooled 18-gauge electrode having a 10-mm active tip. Main outcome measures The VRR was calculated. Technical parameters were the following: median power (P median), effective time of treatment (Teff), energy calculated as Pmedian × Teff (Ecalc), and energy delivered per ml as Kcal × 4184 × nodule’s volume (Edel). Continuous variables were analyzed by the Mann Whitney test. The correlation of the above parameters with VRR was analyzed by linear regression.

Results: Forty-one nodules were included and their VRR 66.6%. RFA was performed with a Pmedian of 55 watts, Teff 10.24 min, Ecalc 31380 Joules, Edel 1473 Joules/mL. Edel was significantly correlated with VRR (P = 0.014) while Pmedian, Teff and Ecalc not. A strong correlation of Edel with VRR was found in nodules <10 ml (P = 0.001) while no significant correlation was observed in nodules >10 ml.

Conclusions: This study showed that the energy delivered with RFA is the only technical parameter significantly correlated with the VRR of thyroid nodules.

Volume 70

22nd European Congress of Endocrinology

Online
05 Sep 2020 - 09 Sep 2020

European Society of Endocrinology 

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