Endocrine Abstracts

Backgroud: Recent studies have shown an association between thyroid hormone levels and non-alcoholic fatty liver disease(NAFLD). However, there have been some inconsistencies between studies. Here, we evaluated the relationship between thyroid hormone levels and NAFLDin euthyroid subjects.

Methods: A retrospective analysis of 27.719 euthyroid subjects who participated in comprehensive health examinations was performed. Subjects were grouped according to thyroid stimulating hormone (TSH) and free thyroxine (FT4). We estimated the odds ratios (OR) for NAFLD according to thyroid hormone quartiles using logistic regression models, adjusted for potential confounders.

Results: Of the study patients, 33% (n = 9.217) had NAFLD. A lower TSH level and higher FT4 level were associated with NAFLD. The proportion of participants with NAFLD decreased across the TSH quartile categories and increased across the FT4 quartile categories. No associations were observed between thyroid hormone and NAFLD after additional adjustment for confounding variables.

Conclusion: Our study demonstrates no significant association between thyroid hormone and NAFLD.